PMID- 16041261
OWN - NLM
STAT- MEDLINE
DCOM- 20050825
LR  - 20220316
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 80
IP  - 2
DP  - 2005 Jul 27
TI  - Characteristic pattern of chromosomal imbalances in posttransplantation 
      lymphoproliferative disorders: correlation with histopathological subcategories 
      and EBV status.
PG  - 176-84
AB  - BACKGROUND: Posttransplantation lymphoproliferative disorders (PTLDs) are a 
      spectrum of lymphoid proliferations, occurring in immunosuppressed organ 
      transplant recipients. They comprise early lesions, polymorphic (P-PTLD), 
      monomorphic (M-PTLD), and Hodgkin/Hodgkin-like lymphoma PTLD (HL-PTLD) lesions. 
      Most of them are associated with Epstein-Barr virus (EBV). Little is known about 
      their genetic changes. MATERIALS AND METHODS: We have studied 35 PTLDs[7 P-PTLDs 
      (3/7 polyclonal IgH), 26 M-PTLDs (22 B-cell PTLD, 4 T-cell PTLD), 2 HL-PTLDs], 
      using comparative genomic hybridization (CGH), a DNA-based technique allowing a 
      screening of chromosomal imbalances without needing cultured cells. RESULTS.: 
      Overall incidence of chromosomal imbalances: 51.5 %. The most frequent gains 
      involved 8q24, 3q27 [4 cases each]; 2p24p25, 5p, 9q22q34, 11, 12q22q24, 14q32, 
      17q, 18q21 [2 cases each]. Nonrandom losses were 17p13 [4 cases]; 1p36, 4q [3 
      cases each]; 17q23q25, Xp [2 cases each]. Three high-level amplifications were 
      detected: 4p16, 9p22p24, 18q21q23. In this latter imbalance, involvement of Bcl2 
      has been confirmed by FISH. The nonrandom CGH imbalances occurring in M-PTLD are 
      usually described in lymphomas of immunocompetent patients and contain genes 
      known to be involved in lymphomagenesis, while genomic abnormalities detected in 
      half cases of EBV positive P-PTLD are mostly unknown. CONCLUSION: This study 
      reported nonrandom chromosomal imbalances in PTLD and also identified early 
      genomic alterations in EBV positive P-PTLD. These results raise two questions: 
      the role of such lesions in the development and progression of those EBV 
      induced-lymphoproliferations and their clinical significance especially in 
      P-PTLD.
FAU - Poirel, Helene A
AU  - Poirel HA
AD  - Centre de genetique, Hematological section of the Center of Human Genetics, 
      Cliniques Universitaires St-Luc-UCL, Bruxelles, Belgium.
FAU - Bernheim, Alain
AU  - Bernheim A
FAU - Schneider, Anouck
AU  - Schneider A
FAU - Meddeb, Mounira
AU  - Meddeb M
FAU - Choquet, Sylvain
AU  - Choquet S
FAU - Leblond, Veronique
AU  - Leblond V
FAU - Charlotte, Frederic
AU  - Charlotte F
FAU - Davi, Frederic
AU  - Davi F
FAU - Canioni, Danielle
AU  - Canioni D
FAU - Macintyre, Elizabeth
AU  - Macintyre E
FAU - Mamzer-Bruneel, Marie-France
AU  - Mamzer-Bruneel MF
FAU - Hirsch, Isabelle
AU  - Hirsch I
FAU - Hermine, Olivier
AU  - Hermine O
FAU - Martin, Antoine
AU  - Martin A
FAU - Cornillet-Lefebvre, Pascale
AU  - Cornillet-Lefebvre P
FAU - Patey, Martine
AU  - Patey M
FAU - Toupance, Olivier
AU  - Toupance O
FAU - Kemeny, Jean-Louis
AU  - Kemeny JL
FAU - Deteix, Patrice
AU  - Deteix P
FAU - Raphael, Martine
AU  - Raphael M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Chromosomal Instability/*genetics
MH  - Chromosome Mapping
MH  - Epstein-Barr Virus Infections/epidemiology
MH  - Female
MH  - Gene Rearrangement
MH  - Genes, Immunoglobulin
MH  - Herpesvirus 4, Human/*isolation & purification
MH  - Humans
MH  - Immunophenotyping
MH  - Infant
MH  - Lymphoproliferative Disorders/*genetics/pathology/virology
MH  - Male
MH  - Middle Aged
MH  - Organ Transplantation/*adverse effects
MH  - Postoperative Complications/physiopathology/virology
MH  - Receptors, Antigen, T-Cell/genetics
MH  - Transplantation Immunology
EDAT- 2005/07/26 09:00
MHDA- 2005/08/27 09:00
CRDT- 2005/07/26 09:00
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - 00007890-200507270-00004 [pii]
AID - 10.1097/01.tp.0000163288.98419.0d [doi]
PST - ppublish
SO  - Transplantation. 2005 Jul 27;80(2):176-84. doi: 
      10.1097/01.tp.0000163288.98419.0d.