PMID- 16041275
OWN - NLM
STAT- MEDLINE
DCOM- 20050825
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 80
IP  - 2
DP  - 2005 Jul 27
TI  - Negative impact of human leukocyte antigen matching in the outcome of 
      polyomavirus nephropathy.
PG  - 276-8
AB  - Factors dependent on the host, the virus, and the allograft affect the course of 
      polyomavirus allograft nephropathy (PVAN). Development of specific cytotoxic 
      antiviral immunity requires recognition of host human leukocyte antigen (HLA) 
      molecules together with viral peptides on the target cells. We correlated the 
      number of matched HLA-A, HLA-B, and HLA-DR antigens with graft outcome in 90 
      patients with PVAN. Patients that maintained graft function had significantly 
      less degrees of HLA matching (mean 1.5) in comparison to patients with graft loss 
      (mean 2.87, P= 0.001). Markedly reduced incidence of graft loss was observed in 
      patients with no HLA matching whatsoever in comparison to patients with any 
      degree of matching (P= 0.003). Lack of HLA matching may impair the host's ability 
      to mount an effective antiviral cytotoxic immune response. An adequately 
      developed antiviral cellular immunity may lead to significant tissue damage and 
      graft loss even if the viral infection is eventually controlled.
FAU - Drachenberg, Cinthia B
AU  - Drachenberg CB
AD  - Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 
      21201, USA.
FAU - Papadimitriou, John C
AU  - Papadimitriou JC
FAU - Mann, Dean
AU  - Mann D
FAU - Hirsch, Hans H
AU  - Hirsch HH
FAU - Wali, Ravinder
AU  - Wali R
FAU - Ramos, Emilio
AU  - Ramos E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Graft Survival
MH  - HLA Antigens/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/*pathology
MH  - Living Donors
MH  - Middle Aged
MH  - Polyomavirus Infections/*physiopathology
MH  - Time Factors
MH  - Transplantation, Homologous
MH  - Treatment Failure
MH  - Treatment Outcome
EDAT- 2005/07/26 09:00
MHDA- 2005/08/27 09:00
CRDT- 2005/07/26 09:00
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - 00007890-200507270-00018 [pii]
AID - 10.1097/01.tp.0000165096.01034.15 [doi]
PST - ppublish
SO  - Transplantation. 2005 Jul 27;80(2):276-8. doi: 10.1097/01.tp.0000165096.01034.15.