PMID- 16041795
OWN - NLM
STAT- MEDLINE
DCOM- 20051026
LR  - 20220408
IS  - 1549-3296 (Print)
IS  - 1549-3296 (Linking)
VI  - 74
IP  - 4
DP  - 2005 Sep 15
TI  - Biocompatibility and degradation of poly(DL-lactic-co-glycolic acid)/calcium 
      phosphate cement composites.
PG  - 533-44
AB  - Injectable calcium phosphate (Ca-P) cement materials exhibit favorable 
      osteocompatible behavior but are resorbed slowly because of a lack of a bone 
      ingrowth-enabling macroporosity. In this study, poly(DL-lactic-co-glycolic acid) 
      (PLGA) microparticles (average size 66 +/- 25 microm) were incorporated into Ca-P 
      cement to obtain a macroporous Ca-P cement scaffold after PLGA hydrolysis in 
      vivo. Preset PLGA/Ca-P cement composite discs of various weight ratios (0/100, 
      15/85, 30/70, and 50/50) were implanted subcutaneously and in cranial defects in 
      rats for 12 weeks. Histological analysis revealed that all macropores in the 
      PLGA-containing composites (average pore size 73 +/- 27 microm) were filled with 
      fibrous tissue and blood vessels (subcutaneous implants) and/or bone (cranial 
      implants). Histologically, bone formation appeared most abundant and most 
      consistent in the 30/70 PLGA/Ca-P cement composites. Histomorphometrical 
      evaluation revealed a significant increase in defect fill in the 15/85 and 30/70 
      PLGA/Ca-P cement composites. Finally, subcutaneous and cranial 50/50 PLGA/Ca-P 
      cement composites had degraded to a large extent, without adequate replacement by 
      bone in the cranial implants. Therefore, we conclude that PLGA/Ca-P cement 
      composites enable tissue ingrowth and show excellent osteocompatibility in weight 
      ratios of 15/85 and 30/70 PLGA/Ca-P cement. In this model, 30/70 PLGA/Ca-P cement 
      composites showed the most favorable biological response.
CI  - (c) 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005.
FAU - Ruhe, P Quinten
AU  - Ruhe PQ
AD  - Department of Biomaterials, Radboud University Nijmegen Medical Center, P.O. Box 
      9101, 6500 HB, Nijmegen, The Netherlands.
FAU - Hedberg, Elizabeth L
AU  - Hedberg EL
FAU - Padron, Nestor Torio
AU  - Padron NT
FAU - Spauwen, Paul H M
AU  - Spauwen PH
FAU - Jansen, John A
AU  - Jansen JA
FAU - Mikos, Antonios G
AU  - Mikos AG
LA  - eng
GR  - R01-AR42639/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - *Absorbable Implants
MH  - Animals
MH  - Bone Substitutes/*metabolism
MH  - Calcium Phosphates/*metabolism
MH  - Lactic Acid/*metabolism
MH  - Male
MH  - *Materials Testing/methods
MH  - Osteogenesis/*physiology
MH  - Polyglycolic Acid/*metabolism
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Tissue Engineering/methods
EDAT- 2005/07/26 09:00
MHDA- 2005/10/27 09:00
CRDT- 2005/07/26 09:00
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2005/10/27 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - 10.1002/jbm.a.30341 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2005 Sep 15;74(4):533-44. doi: 10.1002/jbm.a.30341.