PMID- 16042494
OWN - NLM
STAT- MEDLINE
DCOM- 20060622
LR  - 20181201
IS  - 0743-7463 (Print)
IS  - 0743-7463 (Linking)
VI  - 21
IP  - 16
DP  - 2005 Aug 2
TI  - Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) 
      microchannels.
PG  - 7551-7
AB  - Control of surface properties in microfluidic systems is an indispensable 
      prerequisite for successful bioanalytical applications. Poly(dimethylsiloxane) 
      (PDMS) microfluidic devices are hampered from unwanted adsorption of biomolecules 
      and lack of methods to control electroosmotic flow (EOF). In this paper, we 
      propose different strategies to coat PDMS surfaces with poly(oxyethylene) (POE) 
      molecules of varying chain lengths. The native PDMS surface is pretreated by 
      exposure to UV irradiation or to an oxygen plasma, and the covalent linkage of 
      POE-silanes as well as physical adsorption of a triblock-copolymer (F108) are 
      studied. Contact angle measurements and atomic force microscopy (AFM) imaging 
      revealed homogeneous attachment of POE-silanes and F108 to the PDMS surfaces. In 
      the case of F108, different adsorption mechanisms to hydrophilic and hydrophobic 
      PDMS are discussed. Determination of the electroosmotic mobilities of these 
      coatings in PDMS microchannels prove their use for electrokinetic applications in 
      which EOF reduction is inevitable and protein adsorption has to be suppressed.
FAU - Hellmich, Wibke
AU  - Hellmich W
AD  - Experimental Biophysics and Applied Nanosciences, Physics Faculty, Bielefeld 
      University, Germany.
FAU - Regtmeier, Jan
AU  - Regtmeier J
FAU - Duong, Thanh Tu
AU  - Duong TT
FAU - Ros, Robert
AU  - Ros R
FAU - Anselmetti, Dario
AU  - Anselmetti D
FAU - Ros, Alexandra
AU  - Ros A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Biocompatible Materials)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Silanes)
RN  - 0 (Silicones)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 63148-62-9 (baysilon)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adsorption
MH  - Biocompatible Materials/*chemistry
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Electrochemistry/*methods
MH  - Electrophoresis
MH  - Electrophoresis, Capillary
MH  - Kinetics
MH  - *Microfluidic Analytical Techniques
MH  - Microscopy, Atomic Force
MH  - Osmosis
MH  - Oxygen/chemistry/metabolism
MH  - Polyethylene Glycols/*chemistry
MH  - Silanes/chemistry
MH  - Silicones/*chemistry
MH  - Surface Properties
MH  - Time Factors
MH  - Ultraviolet Rays
EDAT- 2005/07/27 09:00
MHDA- 2006/06/23 09:00
CRDT- 2005/07/27 09:00
PHST- 2005/07/27 09:00 [pubmed]
PHST- 2006/06/23 09:00 [medline]
PHST- 2005/07/27 09:00 [entrez]
AID - 10.1021/la0510432 [doi]
PST - ppublish
SO  - Langmuir. 2005 Aug 2;21(16):7551-7. doi: 10.1021/la0510432.