PMID- 16042809
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20051014
LR  - 20200929
IS  - 1471-2326 (Electronic)
IS  - 1471-2326 (Linking)
VI  - 5
DP  - 2005 Jul 25
TI  - Total blood lymphocyte counts in hemochromatosis probands with HFE C282Y 
      homozygosity: relationship to severity of iron overload and HLA-A and -B alleles 
      and haplotypes.
PG  - 5
LID - 10.1186/1471-2326-5-5 [doi]
AB  - BACKGROUND: It has been reported that some persons with hemochromatosis have low 
      total blood lymphocyte counts, but the reason for this is unknown. METHODS: We 
      measured total blood lymphocyte counts using an automated blood cell counter in 
      146 hemochromatosis probands (88 men, 58 women) with HFE C282Y homozygosity who 
      were diagnosed in medical care. Univariate and multivariate analyses of total 
      blood lymphocyte counts were evaluated using these variables: sex; age, 
      transferrin saturation, and serum ferritin concentration at diagnosis; units of 
      blood removed by phlebotomy to achieve iron depletion; and human leukocyte 
      antigen (HLA)-A and -B alleles and haplotypes. RESULTS: The mean age at diagnosis 
      was 49 +/- 14 years (range 18 - 80 years) in men and 50 +/- 13 years (range 22-88 
      years) in women. The correlations of total blood lymphocyte counts with sex, age, 
      transferrin saturation, and serum ferritin concentration at diagnosis, and units 
      of blood removed by phlebotomy to achieve iron depletion were not significant at 
      the 0.05 level. Univariate analyses revealed significant associations between 
      total blood lymphocyte counts and presence of the HLA-A*01, -B*08, and -B*14 
      alleles, and the A*01-B*08 haplotype. Presence of the A*01 allele, B*08 allele, 
      or A*01-B*08 haplotype were associated with a lower total blood lymphocyte count, 
      whereas presence of the B*14 allele was associated with a greater total blood 
      lymphocyte count. There was an inverse association of total blood lymphocyte 
      count with units of phlebotomy to achieve iron depletion, serum ferritin 
      concentration, and with presence of the A*01-B*08 haplotype. CONCLUSION: We 
      conclude that there is a significant inverse relationship of total blood 
      lymphocyte counts and severity of iron overload in hemochromatosis probands with 
      HFE C282Y homozygosity. The presence of the HLA-A*01 allele or the -B*08 allele 
      was also associated with significantly lower total blood lymphocyte counts, 
      whereas presence of the -B*14 allele was associated with significantly higher 
      total blood lymphocyte counts. In univariate and multivariate analyses, total 
      blood lymphocyte counts were significantly lower in probands with the 
      HLA-A*01-B*08 haplotype than in probands without this haplotype.
FAU - Barton, James C
AU  - Barton JC
AD  - Southern Iron Disorders Center, Birmingham, Alabama, USA.
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 
      USA.
FAU - Wiener, Howard W
AU  - Wiener HW
AD  - Department of Epidemiology and International Health, University of Alabama at 
      Birmingham, Birmingham, Alabama, USA.
FAU - Acton, Ronald T
AU  - Acton RT
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 
      USA.
AD  - Department of Epidemiology and International Health, University of Alabama at 
      Birmingham, Birmingham, Alabama, USA.
AD  - Immunogenetics Program, Department of Microbiology, University of Alabama at 
      Birmingham, Birmingham, Alabama, USA.
FAU - Go, Rodney Cp
AU  - Go RC
AD  - Department of Epidemiology and International Health, University of Alabama at 
      Birmingham, Birmingham, Alabama, USA.
LA  - eng
GR  - R01 MH066181/MH/NIMH NIH HHS/United States
GR  - R01 NS045934/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20050725
PL  - England
TA  - BMC Blood Disord
JT  - BMC blood disorders
JID - 100968550
PMC - PMC1198220
EDAT- 2005/07/27 09:00
MHDA- 2005/07/27 09:01
PMCR- 2005/07/25
CRDT- 2005/07/27 09:00
PHST- 2005/03/10 00:00 [received]
PHST- 2005/07/25 00:00 [accepted]
PHST- 2005/07/27 09:00 [pubmed]
PHST- 2005/07/27 09:01 [medline]
PHST- 2005/07/27 09:00 [entrez]
PHST- 2005/07/25 00:00 [pmc-release]
AID - 1471-2326-5-5 [pii]
AID - 10.1186/1471-2326-5-5 [doi]
PST - epublish
SO  - BMC Blood Disord. 2005 Jul 25;5:5. doi: 10.1186/1471-2326-5-5.