PMID- 16042867
OWN - NLM
STAT- MEDLINE
DCOM- 20051017
LR  - 20161020
IS  - 1008-1275 (Print)
IS  - 1008-1275 (Linking)
VI  - 8
IP  - 4
DP  - 2005 Aug
TI  - Monocyte chemoattractant protein-1 level in serum of patients with acute spinal 
      cord injury.
PG  - 216-9
AB  - OBJECTIVE: To detect the concentration of monocyte chemoattractant protein-1 
      (MCP-1) in the serum of patients with incomplete spinal cord injury and evaluate 
      its relation with the pathologic classification of the spinal cord injury. 
      METHODS: MCP-1 concentration in the serum of patients with incomplete spinal cord 
      injury (iSCI), single spine compression and healthy subjects were detected by 
      ELISA, respectively in the present study and the magnetic resonance imaging data 
      of these patients were studied at the same time on a blind base. RESULTS: Serum 
      level of MCP-1 in iSCI patients was 428 pg/ml +/- 11 pg/ml by ELISA, which was 
      higher than both that of the patients with single spine compression and of 
      controls, with the concentration of 184 pg/ml +/- 21 pg/ml and 124 pg/ml +/- 15 
      pg/ml, respectively. There was significant difference between any two groups (P < 
      0.01). iSCI patients with normal MRI showed a lower serum level of MCP-1 as 312 
      pg/ml+/- 30 pg/ml. Pathological classification of spinal cord edema and hematoma 
      corresponded to 390 pg/ml +/- 16 pg/ml and 508 pg/ml+/- 24 pg/ml in the 
      concentration of MCP-1. CONCLUSIONS: MCP-1 may induce secondary inflammatory 
      response by recruiting inflammatory cells to the injury site and thus affect the 
      prognosis of spinal cord injury.
FAU - Liu, Shi-qing
AU  - Liu SQ
AD  - Deparment of Orthopaedics of Renmin Hospital, Wuhan University, China. 
      martin1354@163.com
FAU - Ma, Yong-gang
AU  - Ma YG
FAU - Peng, Hao
AU  - Peng H
FAU - Fan, Li
AU  - Fan L
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin J Traumatol
JT  - Chinese journal of traumatology = Zhonghua chuang shang za zhi
JID - 100886162
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Spinal Cord Injuries/*blood/pathology
EDAT- 2005/07/27 09:00
MHDA- 2005/10/18 09:00
CRDT- 2005/07/27 09:00
PHST- 2005/07/27 09:00 [pubmed]
PHST- 2005/10/18 09:00 [medline]
PHST- 2005/07/27 09:00 [entrez]
PST - ppublish
SO  - Chin J Traumatol. 2005 Aug;8(4):216-9.