PMID- 16043399
OWN - NLM
STAT- MEDLINE
DCOM- 20051109
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 116
IP  - 9
DP  - 2005 Sep
TI  - Auditory and visual refractory period effects in children and adults: an ERP 
      study.
PG  - 2184-203
AB  - OBJECTIVE: This developmental study was designed to investigate event-related 
      potential (ERP) refractory period effects in the auditory and visual modalities 
      in children and adults and to correlate these electrophysiological measures with 
      standard behavioral measures. METHODS: ERPs, accuracy, and reaction time were 
      recorded as school-age children and adults monitored a stream of repetitive 
      standard stimuli and detected occasional targets. Standards were presented at 
      various interstimulus intervals (ISIs) in order to measure refractory period 
      effects on early sensory components. RESULTS: As has been reported previously in 
      adults, larger components for standards with longer ISIs were observed for an 
      auditory N1 and the visual occipital P1 and P2 in adults. Remarkably similar 
      effects were observed in children. However, only children showed refractory 
      effects on the amplitude of the visual N1 and P2 measured at anterior sites. 
      Across groups, behavioral accuracy and reaction time were correlated with 
      latencies of auditory N1 and visual P2 across ISI conditions. CONCLUSIONS: The 
      results establish a normal course of development for auditory and visual ERP 
      refractory period effects across the 6- to 8-year-old age range and indicate 
      similar refractoriness in the neural systems indexed by ERPs in these paradigms 
      in typically developing children and adults. Further, the results suggest that 
      electrophysiological measures and standard behavioral measures may at least in 
      part index similar processing in the present paradigms. SIGNIFICANCE: These 
      findings provide a foundation for further investigation into atypical 
      development, particularly in those populations for which processing time deficits 
      have been implicated such as children with specific language impairment or 
      dyslexia.
FAU - Coch, Donna
AU  - Coch D
AD  - Brain Development Lab, Department of Psychology, University of Oregon, Eugene OR 
      97403, USA. donna.coch@dartmouth.edu
FAU - Skendzel, Wendy
AU  - Skendzel W
FAU - Neville, Helen J
AU  - Neville HJ
LA  - eng
GR  - DC00481/DC/NIDCD NIH HHS/United States
GR  - HD08598/HD/NICHD NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Aging/physiology
MH  - Child
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Evoked Potentials, Visual/*physiology
MH  - Humans
MH  - Memory/physiology
MH  - Photic Stimulation
MH  - Psychomotor Performance/physiology
MH  - Reaction Time/physiology
MH  - Refractory Period, Electrophysiological/*physiology
EDAT- 2005/07/27 09:00
MHDA- 2005/11/10 09:00
CRDT- 2005/07/27 09:00
PHST- 2003/09/23 00:00 [received]
PHST- 2005/05/26 00:00 [revised]
PHST- 2005/06/03 00:00 [accepted]
PHST- 2005/07/27 09:00 [pubmed]
PHST- 2005/11/10 09:00 [medline]
PHST- 2005/07/27 09:00 [entrez]
AID - S1388-2457(05)00231-2 [pii]
AID - 10.1016/j.clinph.2005.06.005 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2005 Sep;116(9):2184-203. doi: 10.1016/j.clinph.2005.06.005.