PMID- 16045029
OWN - NLM
STAT- MEDLINE
DCOM- 20060901
LR  - 20071115
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 30
IP  - 3
DP  - 2005 Jun
TI  - [Microvessel counts and the expressions of chemotactic factors in the 
      pathological scar tissues].
PG  - 340-3, 348
AB  - OBJECTIVE: To explore the microvessel counts and the expressions of interleukin-8 
      (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory 
      protein-1 ( MIP-1) alpha mRNA in the pathological scar tissues. METHODS: 
      Immunohistochemical method of avidin-biotin complex was used for microvessel 
      counts on the routinely formalin-fixed and paraffin-embedded sections of 
      specimens of hypertrophic scars, keloids, normal skin, and surgical scar, and in 
      situ hybridization for the expressions of IL-8, MCP-1, MIP-1alpha mRNA. RESULTS: 
      The microvessel counts as well as the positive rates and the scorings of IL-8, 
      MCP-1, and MIP-1alpha mRNA were significantly higher in pathological scars than 
      those in the normal skin and surgical scar (all P < 0.05). The microvessel counts 
      were significantly higher in the positive cases of IL-8, MCP-1 and MIP-1alpha 
      mRNA than those in the negative ones (P < 0.05). The close positive correlations 
      were found among the microvessel counts and the expressive scorings of 3 factors 
      (P < 0.05). The close positive correlations were also found among the expressive 
      scorings of IL-8, MCP-1, and MIP-1alpha mRNA in pathological scars. Microvessel 
      counts were significantly higher in hypertrophic scars with the course less than 
      1 year than those with the course more than 1 year. CONCLUSION: IL-8, MCP-1 and 
      MIP-1alpha play important roles in promoting the neovascularization of 
      pathological scars.
FAU - Qian, Li
AU  - Qian L
AD  - Department of Burn and Plastic Surgery, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China. HNFIJ@163.com
FAU - Zhao, Bai-Cheng
AU  - Zhao BC
FAU - Pi, Li
AU  - Pi L
FAU - Lu, Qing
AU  - Lu Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Interleukin-8)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Burns/complications
MH  - Capillaries/metabolism
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Cicatrix/etiology/*metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-8/*biosynthesis/genetics
MH  - Macrophage Inflammatory Proteins/*biosynthesis/genetics
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Skin/*blood supply
EDAT- 2005/07/28 09:00
MHDA- 2006/09/02 09:00
CRDT- 2005/07/28 09:00
PHST- 2005/07/28 09:00 [pubmed]
PHST- 2006/09/02 09:00 [medline]
PHST- 2005/07/28 09:00 [entrez]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun;30(3):340-3, 348.