PMID- 16046118
OWN - NLM
STAT- MEDLINE
DCOM- 20060110
LR  - 20220331
IS  - 0960-0760 (Print)
IS  - 0960-0760 (Linking)
VI  - 97
IP  - 1-2
DP  - 2005 Oct
TI  - Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts.
PG  - 93-101
AB  - 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite 
      of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts 
      other biological activities, including immunomodulation via the nuclear Vitamin D 
      receptor expressed in antigen-presenting cells and activated T cells. This 
      regulation is mediated through interference with nuclear transcription factors 
      such as NF-AT and NF-kappaB or by direct interaction with Vitamin D responsive 
      elements in the promoter regions of cytokine genes. Dendritic cells (DCs) are 
      primary targets for the immunomodulatory activity of 1,25(OH)(2)D(3), as 
      indicated by inhibited DC differentiation and maturation, leading to 
      down-regulated expression of MHC-II, costimulatory molecules and IL-12. Moreover, 
      1,25(OH)(2)D(3) enhances IL-10 production and promotes DC apoptosis. Together, 
      these effects of 1,25(OH)(2)D(3) inhibit DC-dependent T cell activation. 
      Immunomodulation by 1,25(OH)(2)D(3) and its analogs in vivo has been demonstrated 
      in different models of autoimmune diseases and transplantation. Moreover, 
      combining analogs with other immunosuppressants leads to synergism in models of 
      autoimmunity and transplantation. The availability of 1,25(OH)(2)D(3) analogs 
      with immunomodulatory activity at non-hypercalcemic doses may allow exploitation 
      of their immunomodulatory effects in a clinical setting of treatment of 
      autoimmune diseases and prevention of allograft rejection.
FAU - van Etten, Evelyne
AU  - van Etten E
AD  - Laboratory of Experimental Medicine and Endocrinology (LEGENDO), Katholieke 
      Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.
FAU - Mathieu, Chantal
AU  - Mathieu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20050719
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Receptors, Calcitriol)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Calcitriol/analogs & derivatives/deficiency/*immunology
MH  - Humans
MH  - Immune System/*immunology/metabolism
MH  - Receptors, Calcitriol/immunology
RF  - 64
EDAT- 2005/07/28 09:00
MHDA- 2006/01/13 09:00
CRDT- 2005/07/28 09:00
PHST- 2005/07/28 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/07/28 09:00 [entrez]
AID - S0960-0760(05)00226-8 [pii]
AID - 10.1016/j.jsbmb.2005.06.002 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):93-101. doi: 
      10.1016/j.jsbmb.2005.06.002. Epub 2005 Jul 19.