PMID- 16046282
OWN - NLM
STAT- MEDLINE
DCOM- 20051020
LR  - 20061115
IS  - 1568-1637 (Print)
IS  - 1568-1637 (Linking)
VI  - 4
IP  - 3
DP  - 2005 Aug
TI  - Why dietary restriction substantially increases longevity in animal models but 
      won't in humans.
PG  - 339-50
AB  - Caloric restriction (CR) extends maximum longevity and slows aging in mice, rats, 
      and numerous non-mammalian taxa. The apparent generality of the 
      longevity-increasing effects of CR has prompted speculation that similar results 
      could be obtained in humans. Longevity, however, is not a trait that exists in a 
      vacuum; it evolves as part of a life history and the physiological mechanisms 
      that determine longevity are undoubtedly complex. Longevity is intertwined with 
      reproduction and there is a cost to reproduction. The impact of this cost on 
      longevity can be age-independent or age-dependent. Given the complexity of the 
      physiology underlying reproductive costs and other mechanisms affecting life 
      history, it is difficult to construct a simple model for the relationship between 
      the particulars of the physiology involved and patterns of mortality. 
      Consequently, we develop a hypothesis-neutral model describing the relationship 
      between diet and longevity. Applying this general model to the special case of 
      human longevity and diet indicates that the benefits of caloric restriction in 
      humans would be quantitatively small.
FAU - Phelan, John P
AU  - Phelan JP
AD  - Life Sciences Core Curriculum Program, UCLA, Los Angeles, CA 90095-1606, USA. 
      jay@ucla.edu
FAU - Rose, Michael R
AU  - Rose MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - *Age Factors
MH  - Animals
MH  - *Caloric Restriction
MH  - Energy Intake/physiology
MH  - Humans
MH  - Longevity/*physiology
MH  - Models, Animal
MH  - Models, Biological
MH  - Mortality
MH  - Reproduction/physiology
MH  - Species Specificity
MH  - Time Factors
RF  - 51
EDAT- 2005/07/28 09:00
MHDA- 2005/10/21 09:00
CRDT- 2005/07/28 09:00
PHST- 2005/01/26 00:00 [received]
PHST- 2005/04/05 00:00 [revised]
PHST- 2005/04/13 00:00 [accepted]
PHST- 2005/07/28 09:00 [pubmed]
PHST- 2005/10/21 09:00 [medline]
PHST- 2005/07/28 09:00 [entrez]
AID - S1568-1637(05)00012-7 [pii]
AID - 10.1016/j.arr.2005.06.001 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2005 Aug;4(3):339-50. doi: 10.1016/j.arr.2005.06.001.