PMID- 16046815
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20060124
LR  - 20181113
IS  - 1110-7243 (Print)
IS  - 1110-7243 (Linking)
VI  - 2005
IP  - 2
DP  - 2005 Jun 30
TI  - Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.
PG  - 104-12
AB  - The etiological origin of type 2 diabetes mellitus (T2DM) has long been 
      controversial. The body of literature related to T2DM is vast and varied in 
      focus, making a broad epidemiological perspective difficult, if not impossible. A 
      data-mining approach was used to analyze all electronically available scientific 
      literature, over 12 million Medline records, for "objects" such as genes, 
      diseases, phenotypes, and chemical compounds linked to other objects within the 
      T2DM literature but were not themselves within the T2DM literature. The goal of 
      this analysis was to conduct a comprehensive survey to identify novel factors 
      implicated in the pathology of T2DM by statistically evaluating mutually shared 
      associations. Surprisingly, epigenetic factors were among the highest statistical 
      scores in this analysis, strongly implicating epigenetic changes within the body 
      as causal factors in the pathogenesis of T2DM. Further analysis implicates 
      adipocytes as the potential tissue of origin, and cytokines or cytokine-like 
      genes as the dysregulated factor(s) responsible for the T2DM phenotype. The 
      analysis provides a wealth of literature supporting this hypothesis, which-if 
      true-represents an important paradigm shift for researchers studying the 
      pathogenesis of T2DM.
FAU - Wren, Jonathan D
AU  - Wren JD
AD  - Advanced Center for Genome Technology, Department of Botany and Microbiology, The 
      University of Oklahoma, 101 David L Boren Blvd, Rm 2025, Norman, OK 73019, USA. 
      jonathan.wren@ou.edu
FAU - Garner, Harold R
AU  - Garner HR
LA  - eng
GR  - P50 CA070907/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
PMC - PMC1184044
EDAT- 2005/07/28 09:00
MHDA- 2005/07/28 09:01
PMCR- 2005/01/01
CRDT- 2005/07/28 09:00
PHST- 2005/07/28 09:00 [pubmed]
PHST- 2005/07/28 09:01 [medline]
PHST- 2005/07/28 09:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - S1110724304404161 [pii]
AID - 10.1155/JBB.2005.104 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2005 Jun 30;2005(2):104-12. doi: 10.1155/JBB.2005.104.