PMID- 16048492
OWN - NLM
STAT- MEDLINE
DCOM- 20051108
LR  - 20050728
IS  - 0141-9854 (Print)
IS  - 0141-9854 (Linking)
VI  - 27
IP  - 4
DP  - 2005 Aug
TI  - Occurrence of autoantibodies in chronic graft vs. host disease after allogeneic 
      stem cell transplantation.
PG  - 247-9
AB  - Chronic graft vs. host disease (GVHD) remains a major cause of morbidity and 
      mortality after allogeneic stem cell transplantation (SCT). Chronic GVHD (cGVHD) 
      has many similarities to de novo autoimmune disorders. While the presence and 
      association of autoantibodies is well reported in these disorders, their role and 
      clinical use remains a less studied area after SCT. We report the presence of 
      autoantibodies in SCT recipients and a possible association with presence of 
      cGVHD. During routine follow-up visits peripheral blood samples were tested for: 
      rheumatoid factor (RF), antinuclear antibody (ANA), double stranded DNA (dsDNA), 
      antimitochondrial antibody, antismooth muscle antibody (Anti Sm), antiendomysial, 
      antireticulin antibodies, antithyroid peroxidase antibodies and an extractable 
      nuclear antigen screen, in 13 SCT recipients. Six of 13 (46%) patients had one or 
      more autoantibodies. All the patients with antibodies had cGVHD where as none of 
      the patients without cGVHD had any autoantibodies (P = 0.025). Three (23%) 
      patients had only one autoantibody and three (23%) of them had more than one 
      autoantibody. ANA was positive in three (23.3%) patients, double stranded DNA in 
      four (30.7%) patients, RF in one (7.6%) and Anti Sm muscle in two (15.3%) 
      patients. In the present study, autoantibodies were detected predominantly in 
      patients with presence of cGVHD. They also appeared to be more frequent in an 
      unmanipulated graft and so less in patients with a T-cell depleted allograft. In 
      two of 13 patients only there appeared to be an association between the antibody 
      titre and flare up in skin symptoms. In conclusion, this small series raises 
      interesting questions about the presence and role of autoantibodies after SCT and 
      their association with cGVHD.
FAU - Wechalekar, A
AU  - Wechalekar A
AD  - Department of Haematology, Queen Alexandra Hospital, Portsmouth, UK. 
      a.wechalekar@medsch.ucl.ac.uk
FAU - Cranfield, T
AU  - Cranfield T
FAU - Sinclair, D
AU  - Sinclair D
FAU - Ganzckowski, M
AU  - Ganzckowski M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Lab Haematol
JT  - Clinical and laboratory haematology
JID - 7907061
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies/*blood
MH  - Chronic Disease
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/*blood/*complications/immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - *Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Treatment Outcome
EDAT- 2005/07/29 09:00
MHDA- 2005/11/09 09:00
CRDT- 2005/07/29 09:00
PHST- 2005/07/29 09:00 [pubmed]
PHST- 2005/11/09 09:00 [medline]
PHST- 2005/07/29 09:00 [entrez]
AID - CLH699 [pii]
AID - 10.1111/j.1365-2257.2005.00699.x [doi]
PST - ppublish
SO  - Clin Lab Haematol. 2005 Aug;27(4):247-9. doi: 10.1111/j.1365-2257.2005.00699.x.