PMID- 16048546
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20051116
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 206
DP  - 2005 Aug
TI  - Involvement of intestinal dendritic cells in oral tolerance, immunity to 
      pathogens, and inflammatory bowel disease.
PG  - 132-48
AB  - Dendritic cells (DCs) are composed of a family of cells, now recognized to be 
      essential for innate and acquired immunity. DCs at mucosal surfaces have a 
      particular capacity to induce the differentiation of regulatory T cells producing 
      interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) in the 
      steady state (non-infected, non-immunized), yet they retain the capacity to 
      induce effector T cells in response to invasive pathogens. This decision between 
      the induction of active immunity and tolerance will depend on the subpopulation 
      of DC involved and the surface receptors engaged during DC activation and T-cell 
      priming. The local microenvironment will likely play an important role both in 
      defining the DC phenotype and in providing direct signals to responding T cells. 
      Furthermore, DCs in organized mucosal lymphoid tissues preferentially induce the 
      expression of CCR9 and alpha4beta7 on T cells, which results in T-cell homing to 
      the intestinal lamina propria. Finally, DCs may play an important role in the 
      maintenance of abnormal intestinal inflammation either by driving pathogenic 
      T-cell responses in mesenteric lymph nodes or by acting to expand or maintain 
      pathogenic T cells locally at sites of inflammation. In this review, a brief 
      discussion of general issues of DC biology that are pertinent to mucosal immunity 
      is followed by a more in-depth discussion of the phenotype and function of DC 
      populations in the intestine.
FAU - Kelsall, Brian L
AU  - Kelsall BL
AD  - Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National 
      Institutes of Allergy and Infectious Diseases, National Institutes of Health, 
      Bethesda, MD 20892, USA. kelsall@nih.gov
FAU - Leon, Francisco
AU  - Leon F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/microbiology
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunity, Mucosal
MH  - Inflammatory Bowel Diseases/*immunology/*microbiology/pathology
MH  - Intestine, Large/*immunology/microbiology/pathology
MH  - Mouth Mucosa/*cytology/*immunology/microbiology
RF  - 161
EDAT- 2005/07/29 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/07/29 09:00
PHST- 2005/07/29 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/07/29 09:00 [entrez]
AID - IMR292 [pii]
AID - 10.1111/j.0105-2896.2005.00292.x [doi]
PST - ppublish
SO  - Immunol Rev. 2005 Aug;206:132-48. doi: 10.1111/j.0105-2896.2005.00292.x.