PMID- 16048550
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20081121
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 206
DP  - 2005 Aug
TI  - Rapidly changing perspectives about mast cells at mucosal surfaces.
PG  - 190-203
AB  - Mast cells (MCs) are major effector cells of immunoglobulin E (IgE)-mediated 
      allergic inflammation. However, it has become increasingly clear that they also 
      play important roles in diverse physiological and pathological processes. Recent 
      advances have focused on the importance of MCs in both innate and adaptive immune 
      responses and have fostered studies of MCs beyond the myopic focus on allergic 
      reactions. MCs possess a variety of surface receptors and may be activated by 
      inflammatory mediators, IgE, IgG, light chains, complement fragments, proteases, 
      hormones, neuropeptides, and microbial products. Following activation, they 
      produce a plethora of pro-inflammatory mediators and participate in inflammatory 
      reactions in many organs. This review focuses on the role of MCs in inflammatory 
      reactions in mucosal surfaces with particular emphasis on their role in 
      respiratory and gastrointestinal inflammatory conditions.
FAU - Vliagoftis, Harissios
AU  - Vliagoftis H
AD  - Department of Medicine, Pulmonary Research Group, University of Alberta, 
      Edmonton, Alberta, Canada.
FAU - Befus, A Dean
AU  - Befus AD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunity, Innate
MH  - Immunity, Mucosal
MH  - Mast Cells/*cytology/*immunology
MH  - Mucous Membrane/cytology/immunology
RF  - 150
EDAT- 2005/07/29 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/07/29 09:00
PHST- 2005/07/29 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/07/29 09:00 [entrez]
AID - IMR279 [pii]
AID - 10.1111/j.0105-2896.2005.00279.x [doi]
PST - ppublish
SO  - Immunol Rev. 2005 Aug;206:190-203. doi: 10.1111/j.0105-2896.2005.00279.x.