PMID- 16049975
OWN - NLM
STAT- MEDLINE
DCOM- 20060111
LR  - 20160303
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 118
IP  - 2
DP  - 2006 Jan 15
TI  - Exploitation of interleukin-18 by gastric cancers for their growth and evasion of 
      host immunity.
PG  - 388-95
AB  - Interleukin-18 (IL-18) is a pleiotropic cytokine that enhances Th1 or Th2 immune 
      response. We show a novel mechanism of gastric cancer cells that allows their 
      immune escape utilizing IL-18. All 4 gastric cancer cell lines, but not colon 
      lines, constitutively expressed IL-18 receptors and IL-18 dose-dependently 
      enhanced their in vitro proliferation accompanied by nuclear factor kappaB 
      activation. When IL-18-pretreated gastric cancer cells were cultured with 
      cytokine-activated peripheral blood killer lymphocytes, the antitumor 
      machineries, perforin or interferon-gamma production of killer lymphocytes 
      decreased, resulting in a decreased susceptibility of cancer cells to killer 
      lymphocytes. Furthermore, gastric cancer cells cultured with IL-18 showed an 
      increased expression of a granzyme B inhibitor, protease inhibitor 9. IL-18 
      injections into severe combined immuno-deficient mice intraperitoneally 
      inoculated with gastric cancer cells consistently decreased the mouse survival 
      time. Our results indicate that gastric cancers exploit IL-18 to grow/invade and 
      evade immunosurveillance in the hosts.
CI  - Copyright 2005 Wiley-Liss, Inc.
FAU - Majima, Takashi
AU  - Majima T
AD  - Department of Surgery I, National Defense Medical College, Tokorozawa, Japan. 
      majima@ndmc.ac.jp
FAU - Ichikura, Takashi
AU  - Ichikura T
FAU - Chochi, Kentaro
AU  - Chochi K
FAU - Kawabata, Toshinobu
AU  - Kawabata T
FAU - Tsujimoto, Hironori
AU  - Tsujimoto H
FAU - Sugasawa, Hidekazu
AU  - Sugasawa H
FAU - Kuranaga, Noritsugu
AU  - Kuranaga N
FAU - Takayama, Eiji
AU  - Takayama E
FAU - Kinoshita, Manabu
AU  - Kinoshita M
FAU - Hiraide, Hoshio
AU  - Hiraide H
FAU - Seki, Shuhji
AU  - Seki S
FAU - Mochizuki, Hidetaka
AU  - Mochizuki H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Interleukin-18)
RN  - 0 (SERPINB9 protein, human)
RN  - 0 (Serpins)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Colonic Neoplasms/immunology
MH  - Disease Progression
MH  - Flow Cytometry
MH  - Gene Expression Profiling
MH  - Humans
MH  - Immunohistochemistry
MH  - Injections, Intraperitoneal
MH  - Interleukin-18/*immunology
MH  - Mice
MH  - Mice, SCID
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serpins/biosynthesis
MH  - Stomach Neoplasms/*immunology/*pathology
MH  - Survival Analysis
MH  - Tumor Cells, Cultured
MH  - Tumor Escape/*immunology
EDAT- 2005/07/29 09:00
MHDA- 2006/01/13 09:00
CRDT- 2005/07/29 09:00
PHST- 2005/07/29 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/07/29 09:00 [entrez]
AID - 10.1002/ijc.21334 [doi]
PST - ppublish
SO  - Int J Cancer. 2006 Jan 15;118(2):388-95. doi: 10.1002/ijc.21334.