PMID- 16050467
OWN - NLM
STAT- MEDLINE
DCOM- 20050819
LR  - 20161124
IS  - 1343-3490 (Print)
IS  - 1343-3490 (Linking)
VI  - 43
IP  - 7
DP  - 2005 Jul
TI  - [A case of effective readministration of itraconazole for recurrent allergic 
      bronchopulmonary aspergillosis].
PG  - 412-6
AB  - A 67-year-old woman suffered from productive cough but not from bronchial asthma. 
      Her peripheral blood showed eosinophilia, a high serum level of total 
      immunoglobulin E (IgE), and elevated specific IgE and positive precipitating 
      antibody against Aspergillus fumigatus. Her chest radiograph and computed 
      tomography revealed infiltrative shadows but not central bronchiectasis. 
      Fibreoptic bronchoscopy detected some mucous plugs which grew Aspergillus 
      fumigatus on culture. We therefore made a diagnosis of allergic bronchopulmonary 
      aspergillosis (ABPA). We treated her using only itraconazole. Her respiratory 
      symptoms, eosinophilia, serum IgE level, and pulmonary infiltration gradually 
      improved, but withdrawal of itraconazole exacerbated her respiratory symptom and 
      laboratory data. Administration of itraconazole again resulted in improvement of 
      her symptoms and laboratory data. We report a case of ABPA without bronchial 
      asthma or central bronchiectasis and refer to our diagnostic rationale. 
      Furthermore, we discuss the decrease of allergens by the eradication of 
      Aspergillus fumigatus in the airway with itraconazole to reduce the allergic 
      reaction and improve the clinical symptoms.
FAU - Uji, Masato
AU  - Uji M
AD  - Department of Internal Medicine, Izumi City Hospital.
FAU - Sugama, Yoshimi
AU  - Sugama Y
FAU - Nishida, Keiko
AU  - Nishida K
FAU - Matsushita, Haruhiko
AU  - Matsushita H
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Nihon Kokyuki Gakkai Zasshi
JT  - Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
JID - 9808802
RN  - 0 (Antifungal Agents)
RN  - 304NUG5GF4 (Itraconazole)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Antifungal Agents/*therapeutic use
MH  - Aspergillosis, Allergic Bronchopulmonary/diagnostic imaging/*drug therapy
MH  - Aspergillus fumigatus/immunology/isolation & purification
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Itraconazole/*therapeutic use
MH  - Radiography, Thoracic
MH  - Recurrence
MH  - Tomography, X-Ray Computed
EDAT- 2005/07/30 09:00
MHDA- 2005/08/20 09:00
CRDT- 2005/07/30 09:00
PHST- 2005/07/30 09:00 [pubmed]
PHST- 2005/08/20 09:00 [medline]
PHST- 2005/07/30 09:00 [entrez]
PST - ppublish
SO  - Nihon Kokyuki Gakkai Zasshi. 2005 Jul;43(7):412-6.