PMID- 16051534
OWN - NLM
STAT- MEDLINE
DCOM- 20051207
LR  - 20191109
IS  - 1061-186X (Print)
IS  - 1026-7158 (Linking)
VI  - 13
IP  - 4
DP  - 2005 May
TI  - Influence of the vehicle on the properties and efficacy of microparticles 
      containing amphotericin B.
PG  - 225-33
AB  - New microparticles containing amphotericin B (AMB) have been developed and 
      manufactured by spray drying. To this end albumin, polylactic-co-glycolic acids 
      (PLGA) and poly(sebacic anhydride) have been employed as drug carriers. The 
      selection of the solvent used to disperse the drug and the vehicle before spray 
      drying was critical on production yields and physical properties of the 
      microparticles. Once particle size, morphology and dispersability in some aqueous 
      media were shown to be acceptable for an intravenous administration, in vivo 
      efficacy was evaluated and compared with the reference medicine Fungizone. 
      Microparticles prepared with albumin, albumin heated at a high temperature, some 
      kinds of PLGA or polyanhydride, as well as Fungizone, were tested in an 
      experimental hamster model of infection with Leishmania infantum, by evaluating 
      the evolution of parasitic burdens in spleen, liver and antibody responses. After 
      the injection of three doses corresponding to 2 mg of AMB per kilogram each, 
      diverse reactions were reported depending on the vehicle. The best 
      dispersability, reduction of parasites and antibody response were achieved when 
      the treatment was performed with AMB in albumin microspheres.
FAU - Sanchez-Brunete, J A
AU  - Sanchez-Brunete JA
AD  - Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, 
      Complutense University, Madrid, 28040, Spain.
FAU - Dea, M A
AU  - Dea MA
FAU - Rama, S
AU  - Rama S
FAU - Bolas, F
AU  - Bolas F
FAU - Alunda, J M
AU  - Alunda JM
FAU - Torrado-Santiago, S
AU  - Torrado-Santiago S
FAU - Torrado, J J
AU  - Torrado JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Albumins)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Polyanhydrides)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7XU7A7DROE (Amphotericin B)
SB  - IM
MH  - Albumins/pharmacokinetics
MH  - Amphotericin B/administration & dosage/*pharmacokinetics/therapeutic use
MH  - Animals
MH  - Antigens, Protozoan/analysis
MH  - Antiprotozoal Agents/administration & dosage/*pharmacokinetics/therapeutic use
MH  - Cricetinae
MH  - Drug Carriers/*pharmacokinetics
MH  - Drug Compounding
MH  - Lactic Acid/pharmacokinetics
MH  - Leishmania infantum/drug effects
MH  - Leishmaniasis, Visceral/*drug therapy/metabolism
MH  - Liver/*metabolism/parasitology
MH  - Male
MH  - Mesocricetus
MH  - Microspheres
MH  - Particle Size
MH  - Polyanhydrides/pharmacokinetics
MH  - Polyglycolic Acid/pharmacokinetics
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/pharmacokinetics
MH  - Spleen/*metabolism/parasitology
EDAT- 2005/07/30 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/07/30 09:00
PHST- 2005/07/30 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/07/30 09:00 [entrez]
AID - W811637484418083 [pii]
AID - 10.1080/10611860500097107 [doi]
PST - ppublish
SO  - J Drug Target. 2005 May;13(4):225-33. doi: 10.1080/10611860500097107.