PMID- 1605191
OWN - NLM
STAT- MEDLINE
DCOM- 19920716
LR  - 20190902
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 43
IP  - 1-2
DP  - 1992 Apr 15-May 1
TI  - Limited size of the fragile X site shown by fluorescence in situ hybridization.
PG  - 187-91
AB  - Cosmids, isolated from a 475 kb YAC that spans the fragile X region, and the YAC 
      itself, were used for fluorescence in situ hybridization (FISH) on metaphase 
      chromosomes from fragile X patients. Cosmid 22.3, containing most of the hybrid 
      translocation breakpoints, shows in situ hybridization signals distal and 
      proximal from the fragile X site. We propose that the size of the fragile site is 
      limited to 20 kb.
FAU - Verkerk, A J
AU  - Verkerk AJ
AD  - Department of Clinical Genetics, University Hospital, Dijkzigt, The Netherlands.
FAU - Eussen, B H
AU  - Eussen BH
FAU - Van Hemel, J O
AU  - Van Hemel JO
FAU - Oostra, B A
AU  - Oostra BA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (DNA, Fungal)
SB  - IM
MH  - Chromosome Fragile Sites
MH  - *Chromosome Fragility
MH  - Chromosome Mapping
MH  - Cosmids
MH  - DNA, Fungal/genetics
MH  - Fluorescence
MH  - Fragile X Syndrome/*genetics
MH  - Genetic Techniques
MH  - Humans
MH  - Male
MH  - Nucleic Acid Hybridization
MH  - *X Chromosome
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
AID - 10.1002/ajmg.1320430131 [doi]
PST - ppublish
SO  - Am J Med Genet. 1992 Apr 15-May 1;43(1-2):187-91. doi: 10.1002/ajmg.1320430131.