PMID- 16053780
OWN - NLM
STAT- MEDLINE
DCOM- 20091215
LR  - 20161124
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 33
IP  - 6
DP  - 2005 Jun
TI  - [Correlation between B-natriuretic peptide and hemodynamics in patients with 
      decompensated heart failure and clinical significance].
PG  - 502-4
AB  - OBJECTIVE: To determine the correlation between the serum level of B-natriuretic 
      peptide (BNP) and hemodynamic variables and to evaluate the diagnostic value of 
      BNP in patients with decompensated heart failure (HF). METHODS: BNP levels 
      (TRIAGE BIOSITE Diagnostics, San Diego, USA) were obtained by a rapid 
      immunofluorescence assay in 117 patients with dyspnea including cardiogenic group 
      (75 patients) and lung disease (42 patients). Hemodynamic parameters of 53 
      patients [male 28, female 25, mean age (71.6 +/- 9.8) years] with HF were 
      determined and left ventricular end-diastolic diameter (LVEDD) of all patients 
      were measured by echocardiogram. RESULTS: Pulmonary capillary wedge pressure 
      (PCWP, mm Hg), mean pulmonary arterial pressure (MPAP, mm Hg), right atrial 
      pressure (RAP, mm Hg) and BNP (ng/L) levels according to New York Heart 
      Association (NYHA) class were: 16.10 +/- 3.50, 22.50 +/- 4.68, 3.11 +/- 1.90, 
      271.25 +/- 159.29 in NYHA class II, respectively; 21.50 +/- 4.42, 28.60 +/- 9.35, 
      8.95 +/- 3.86, 619.58 +/- 237.48 in NYHA class III; 29.28 +/- 8.61, 36.50 +/- 
      12.32, 15.27 +/- 4.96, 1519.28 +/- 618.62 in NYHA class IV (P < 0.01-0.05), 
      respectively. PCWP, MPAP, RAP and plasma BNP levels were directly proportional to 
      cardiac function. The plasma BNP levels had also significant positive 
      correlations with PCWP, MPAP, RAP, (r = 0.59, 0.50, 0.32, P < 0.05-0.01). BNP 
      level [(918.48 +/- 453.25) ng/L] of the group with LVEDD (n = 24) > or = 60 mm 
      was much higher than that of the group with LVEDD (n = 29) < 60 mm [(298.58 +/- 
      167.51) ng/L]. However, the latter was significantly higher than that in 
      pulmonary dyspnea group with a normal left and right ventricular end-diastolic 
      diameter [(35.4 +/- 26.4) ng/L, P < 0.01]. There was a great difference of BNP 
      between cardiogenic dyspnea group [(761.30 +/- 480.47) ng/L]and lung dyspnea 
      group [(35.4 +/- 26.4) ng/L], P < 0.01. CONCLUSIONS: The plasma BNP levels had 
      significant positive correlations with PCWP, MPAP, RAP. BNP is a cardiac 
      neurohormone secreted from cardiac ventricles as a response to ventricular volume 
      expansion and pressure overload. Rapid testing BNP should be of help to 
      differentiate pulmonary dyspnea from cardiac etiologies.
FAU - Zhao, Si-qin
AU  - Zhao SQ
AD  - Department of Cardiology, Second People's Hospital of Chengdu, Chengdu 610017, 
      China.
FAU - Li, Qiu
AU  - Li Q
FAU - Wu, Tao
AU  - Wu T
FAU - Liu, Xiao-rong
AU  - Liu XR
FAU - Zhao, Ning
AU  - Zhao N
FAU - Nie, Xiao-li
AU  - Nie XL
FAU - Wang, Mian
AU  - Wang M
FAU - Hu, Yong-mei
AU  - Hu YM
LA  - chi
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Ultrasonography
EDAT- 2005/08/02 09:00
MHDA- 2009/12/16 06:00
CRDT- 2005/08/02 09:00
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Jun;33(6):502-4.