PMID- 16053786
OWN - NLM
STAT- MEDLINE
DCOM- 20091215
LR  - 20150529
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 33
IP  - 6
DP  - 2005 Jun
TI  - [The significance of Th1/Th2 function imbalance in patients with post-infarction 
      cardiac insufficiency].
PG  - 526-8
AB  - OBJECTIVE: To study the significance of Th1/Th2 function imbalance in patients 
      with post-infarction cardiac insufficiency. METHODS: Forty-three MI (myocardial 
      infarction) patients were divided into 2 groups one month after the onset 
      according to the New York Heart Association (NYHA) classification system: group 
      MI 1 (I, II) 25 patients and group MI 2 (III, IV) 18 patients. At the same time, 
      the heart function was evaluated by two-dimensional echocardiography. Peripheral 
      blood mononuclear cells (PBMCs) were collected from these patients. 
      Cytokine-producing CD4 + T cells were quantified by 3-color flow cytometry after 
      being stimulated with phorbol myristate acetate (PMA) and ionomycin. After being 
      stimulated with PHA, the levels of IFN-gamma and IL-4 in culture supernatants 
      were measured by ELISA. RESULTS: The frequencies of IFN-gamma-producing T cells 
      were found to be significantly higher in group MI 2 (16.8%) than that in group MI 
      1 (13.1%). There was no significant difference on the frequencies of 
      IL-4-producing peripheral T cells between the two groups. The IFN-gamma level and 
      the ratios of IFN-gamma/IL-4 in group MI 2 were significantly higher than those 
      in group MI 1, while there was no significant difference in IL-4 levels between 
      the two groups. CONCLUSIONS: The Th-cell function was associated with heart 
      function in post MI patients. The up-regulation of Th1 cell function was 
      consistent with poor heart function, suggesting that Th1/Th2 cell function 
      imbalance may participate in ventricular remodelling after MI.
FAU - Cheng, Xiang
AU  - Cheng X
AD  - Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, 
      Tongji Medical College of Huazhong University of Science and Technology, Wuhan 
      430022, China.
FAU - Liao, Yu-hua
AU  - Liao YH
FAU - Li, Bin
AU  - Li B
FAU - Zhang, Jin-ying
AU  - Zhang JY
FAU - Ge, Hong-xia
AU  - Ge HX
FAU - Yuan, Jing
AU  - Yuan J
FAU - Wang, Min
AU  - Wang M
FAU - Liu, Ying
AU  - Liu Y
FAU - Guo, Zhang-qiang
AU  - Guo ZQ
FAU - Chen, Jing
AU  - Chen J
FAU - Zhang, Jin
AU  - Zhang J
FAU - Chen, Peng
AU  - Chen P
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
RIN - Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Nov;41(11):949. PMID: 24370225
MH  - Aged
MH  - CD4-Positive T-Lymphocytes/*metabolism
MH  - Female
MH  - Heart Failure/etiology/*immunology/*physiopathology
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Interleukin-4/metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*immunology
MH  - Th1 Cells
MH  - Th2 Cells
EDAT- 2005/08/02 09:00
MHDA- 2009/12/16 06:00
CRDT- 2005/08/02 09:00
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Jun;33(6):526-8.