PMID- 16053787
OWN - NLM
STAT- MEDLINE
DCOM- 20091215
LR  - 20171116
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 33
IP  - 6
DP  - 2005 Jun
TI  - [PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left 
      ventricular hypertrophy in subjects with metabolic syndrome].
PG  - 529-33
AB  - OBJECTIVE: To investigate the relationship between PPARdelta + 294T/C gene 
      polymorphism and lipid profile, obesity and left ventricular hypertrophy (LVH) in 
      patients with metabolic syndrome (MS). METHODS: This study was conducted in 300 
      patients with MS and 174 patients with essential hypertension (EH) and 143 
      patients with type 2 diabetes mellitus (T2DM). MS was diagnosed according to 1999 
      WHO criteria. Fasting insulin (FINS), fasting blood glucose (FBG), plasma lipids 
      levels were measured, LVH was examined by Doppler echocardiography. The PPARdelta 
      + 294T/C gene polymorphism were analyzed using polymerase chain reaction and 
      subsequently digested by BSLI restriction endonuclease. RESULTS: The frequencies 
      of the PPARdelta + 294T/C genotypes were not different among three groups. 
      Compared with T2DM and EH, MS patients had significantly higher body mass index 
      (BMI), plasma total cholesterol, TG and LDL-C levels (P < 0.01 or P < 0.05). LVM, 
      LVMI and incidence rate of LVH were significantly higher in MS and EH patients 
      than that in T2DM (P < 0.01). MS patients with CC genotype had significantly 
      higher total cholesterol and LDL-C levels than those with TT and TC genotypes 
      (total cholesterol in CC genotype: 6.13 +/- 1.86 mmol/L vs in TC genotype: 5.14 
      +/- 1.10 mmol/L, P < 0.05, and CC genotype: 6.13 +/- 1.86 mmol/L vs TT genotype: 
      4.99 +/- 1.42 mmol/L, P < 0.01; LDL-C in CC genotype: 3.82 +/- 1.52 mmol/L vs in 
      TC genotype: 3.14 +/- 0.88 mmol/L, P < 0.05, and in CC genotype: 3.82 +/- 1.52 
      mmol/L vs in TT genotype: 2.90 +/- 0.87 mmol/L, P < 0.01). BMI and LVMI in MS 
      patients with C allele carriers (CC + TC) were significantly higher than that of 
      TT genotype (LVMI in CC + TC: 46 +/- 10 g/m(2.7) vs in TT: 44 +/- 10 g/m(2.7); 
      BMI in CC + TC: 26 +/- 3 kg/m(2) vs in TT: 25 +/- 3 kg/m(2), P < 0.05). 
      CONCLUSIONS: It is indicated that PPARdelta + 294T/C gene polymorphism in 
      subjects with MS may be involved in the occurrence of obesity and dyslipidemia. 
      MS patients with C allele had a predominant LVH than subjects with TT genotype.
FAU - Yan, Zhen-cheng
AU  - Yan ZC
AD  - Department of Hypertension and Endocrinology, Chongqing Institute of 
      Hypertension, Daping Hospital, Third Military Medical University, Chongqing 
      400042, China.
FAU - Shen, Cheng-yi
AU  - Shen CY
FAU - Zhong, Jian
AU  - Zhong J
FAU - Wang, Ling
AU  - Wang L
FAU - Ni, Yin-xing
AU  - Ni YX
FAU - Nie, Hai
AU  - Nie H
FAU - Zhu, Zhi-ming
AU  - Zhu ZM
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0 (Lipids)
RN  - 0 (PPAR delta)
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/genetics/physiopathology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*genetics/physiopathology
MH  - Lipids/*blood
MH  - Male
MH  - Metabolic Syndrome/*genetics/physiopathology
MH  - Middle Aged
MH  - Obesity/*genetics/physiopathology
MH  - PPAR delta/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Ventricular Remodeling
EDAT- 2005/08/02 09:00
MHDA- 2009/12/16 06:00
CRDT- 2005/08/02 09:00
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Jun;33(6):529-33.