PMID- 16054351
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20061115
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 17
IP  - 5
DP  - 2005 Oct
TI  - Several genes in the extended human MHC contribute to predisposition to 
      autoimmune diseases.
PG  - 526-31
AB  - Autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, psoriasis and 
      systemic lupus erythematosus, affect approximately 4% of the population in 
      industrialized countries, and are characterized by an immune-mediated destruction 
      of autologous cells and/or tissues. More knowledge is needed to prevent and treat 
      this large group of diseases. Unravelling the genetic predisposing factors is 
      important in this respect, and large research efforts have been initiated to 
      reach this goal. The human MHC, also called the human leukocyte antigen (HLA) 
      complex, is known to harbour major genetic determinants for autoimmune diseases. 
      For several autoimmune diseases certain classical HLA class II and/or class I 
      genes are strongly associated with disease. As a result of recent systematic 
      screening studies additional genes and regions in the MHC, including the extended 
      MHC, are now known to contribute to the predisposition.
FAU - Lie, Benedicte A
AU  - Lie BA
AD  - Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, 
      Norway. b.a.lie@medisin.uio.no
FAU - Thorsby, Erik
AU  - Thorsby E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Autoimmune Diseases/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Histocompatibility Antigens/genetics/immunology
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
RF  - 51
EDAT- 2005/08/02 09:00
MHDA- 2005/10/28 09:00
CRDT- 2005/08/02 09:00
PHST- 2005/05/16 00:00 [received]
PHST- 2005/07/18 00:00 [accepted]
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
AID - S0952-7915(05)00105-6 [pii]
AID - 10.1016/j.coi.2005.07.001 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2005 Oct;17(5):526-31. doi: 10.1016/j.coi.2005.07.001.