PMID- 16054424
OWN - NLM
STAT- MEDLINE
DCOM- 20060316
LR  - 20220410
IS  - 1368-8375 (Print)
IS  - 1368-8375 (Linking)
VI  - 41
IP  - 9
DP  - 2005 Oct
TI  - Differential KIT expression in histological subtypes of adenoid cystic carcinoma 
      (ACC) of the salivary gland.
PG  - 934-9
AB  - Adenoid cystic carcinoma (ACC) of the salivary gland is characterized by a 
      prolonged but inevitably unfavorable clinical course. Recent studies suggested 
      the transmembrane tyrosine kinase KIT to be involved in ACC pathogenesis. To 
      investigate KIT expression in histologically defined subgroups of ACC and to 
      clarify whether KIT gene copy number gain contributes to KIT overexpression, 
      tumor tissue microarray sections including 55 ACC tumors were analyzed by 
      fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). The 
      prevalence of positive KIT immunostaining was 89% (49/55). Strong immunostaining 
      of KIT was only found in cribriform and tubular but never in solid subtypes 
      (p=0.02). Average KIT staining intensity was higher in cribriform and tubular 
      (n=37) compared to solid (n=18) ACC subtypes (p=0.005). FISH analysis revealed 
      copy number gains of the KIT gene in 6.1% (3/49) of tumors analyzed. Our results 
      implicate that specific KIT tyrosine kinase inhibitors such as imatinib, might be 
      used in future therapeutic approaches against subgroups of ACC.
FAU - Freier, Kolja
AU  - Freier K
AD  - Abteilung Molekulare Genetik (B060), Deutsches Krebsforschungszentrum, 69120 
      Heidelberg, Germany.
FAU - Flechtenmacher, Christa
AU  - Flechtenmacher C
FAU - Walch, Axel
AU  - Walch A
FAU - Devens, Frauke
AU  - Devens F
FAU - Muhling, Joachim
AU  - Muhling J
FAU - Lichter, Peter
AU  - Lichter P
FAU - Joos, Stefan
AU  - Joos S
FAU - Hofele, Christof
AU  - Hofele C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
SB  - IM
MH  - Carcinoma, Adenoid Cystic/genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Microarray Analysis/methods
MH  - Proto-Oncogene Proteins c-kit/*metabolism
MH  - Salivary Gland Neoplasms/genetics/*metabolism
EDAT- 2005/08/02 09:00
MHDA- 2006/03/17 09:00
CRDT- 2005/08/02 09:00
PHST- 2005/05/04 00:00 [received]
PHST- 2005/05/16 00:00 [accepted]
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2006/03/17 09:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
AID - S1368-8375(05)00147-8 [pii]
AID - 10.1016/j.oraloncology.2005.05.005 [doi]
PST - ppublish
SO  - Oral Oncol. 2005 Oct;41(9):934-9. doi: 10.1016/j.oraloncology.2005.05.005.