PMID- 16054771
OWN - NLM
STAT- MEDLINE
DCOM- 20051114
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 134
IP  - 3
DP  - 2005
TI  - Ethanol modulates the expression of GABA(B) receptor mRNAs in the prenatal rat 
      brain in an age and area dependent manner.
PG  - 857-66
AB  - Prenatal ethanol exposure has various deleterious effects on neuronal 
      development. As GABA(B) receptor is known to play an important role during the 
      development of the CNS, we now focused on its mRNA expression pattern in the rat 
      brain during the late gestational days (GD) from 15.5 to GD 21.5. Ethanol's 
      effect was also observed from GD 11.5 to GD 21.5. GABA(B1) receptor mRNA showed a 
      high expression level in GD 15.5 and 19.5, while GABA(B2) receptor mRNA did in GD 
      15.5 and 21.5. The mRNAs levels depended on age and area during development. 
      Ethanol exposure decreased GABA(B1) receptor from GD 11.5 to GD 19.5 with slight 
      increases in GD 21.5. The decreasing effects were area dependent, with the 
      highest effects in the forebrain including cortex, whereas slight effects were 
      observed in the midbrain and hindbrain. The present results suggest an important 
      role of GABA(B) receptor in the effects of ethanol on prenatal brain 
      developmental processes.
FAU - Li, S P
AU  - Li SP
AD  - Division of Life Science, College of Natural Sciences and Applied Life Science 
      (Brain Korea 21), Gyeongsang National University, Gyeongnam, Chinju, 660-701, 
      South Korea.
FAU - Kim, J H
AU  - Kim JH
FAU - Park, M S
AU  - Park MS
FAU - Bahk, J Y
AU  - Bahk JY
FAU - Chung, B C
AU  - Chung BC
FAU - Kim, M O
AU  - Kim MO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, GABA-A)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Blotting, Northern/methods
MH  - Brain/anatomy & histology/*drug effects/metabolism
MH  - Central Nervous System Depressants/*pharmacology
MH  - Embryo, Mammalian
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - In Situ Hybridization/methods
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, GABA-A/*genetics
EDAT- 2005/08/02 09:00
MHDA- 2005/11/15 09:00
CRDT- 2005/08/02 09:00
PHST- 2005/01/14 00:00 [received]
PHST- 2005/05/04 00:00 [revised]
PHST- 2005/05/05 00:00 [accepted]
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2005/11/15 09:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
AID - S0306-4522(05)00509-9 [pii]
AID - 10.1016/j.neuroscience.2005.05.001 [doi]
PST - ppublish
SO  - Neuroscience. 2005;134(3):857-66. doi: 10.1016/j.neuroscience.2005.05.001.