PMID- 16055165
OWN - NLM
STAT- MEDLINE
DCOM- 20060410
LR  - 20061115
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 62
IP  - 7
DP  - 2006 Feb
TI  - Linking molecular interactions to consequent effects of persistent organic 
      pollutants (POPs) upon populations.
PG  - 1033-42
AB  - There is great concern about the potential adverse effects of persistent organic 
      pollutants (POPs) on wildlife. Threats come from toxic chemicals with long half 
      lives in the environment that were released worldwide on a large scale in the 
      past, at a time when little was known of their potential effects on the 
      environment. Although the Stockholm Convention (2001) initially targeted 12 POP 
      chemicals--organochlorinated compounds--for the reduction/elimination of 
      releases, the problem can be extended to persistent toxic substances more 
      generally. Therefore, identifying early biomarkers for possible toxic effects to 
      populations in the long term is a challenge for ecotoxicologists. Regional 
      decline in fish, bird and/or invertebrate populations resulting from exposure to 
      POPs, such as DDT (dichlorodiphenyltrichloroethane), PCBs (polychlorinated 
      biphenyls), PCDD (polychlorinated dibenzo-p-dioxins), and TBT (tributyltin) could 
      be related to some biochemical, endocrine and physiological effects in 
      individuals. Examples of known mechanisms of POP ecotoxicity will be illustrated 
      in the first part. The next parts will be devoted to (i) data gaps and 
      limitations to extrapolation from lower to higher levels of biological 
      organization, (ii) confusing factors in field studies and the combined effects of 
      persistent toxic pollutants and (iii) recommendations for the design and 
      interpretation of experimental studies.
FAU - Vasseur, Paule
AU  - Vasseur P
AD  - Lab. ESE, CNRS UMR 7146, Faculty of Sciences, Universite de Metz, Rue 
      Delestraint, F-57070 Metz, France. vasseur@univ-metz.fr
FAU - Cossu-Leguille, Carole
AU  - Cossu-Leguille C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20050801
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Animals
MH  - Ecosystem
MH  - Endocrine Disruptors/*toxicity
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*toxicity
MH  - Humans
MH  - Organic Chemicals/*toxicity
MH  - *Population Density
MH  - Reproduction/*drug effects
RF  - 37
EDAT- 2005/08/02 09:00
MHDA- 2006/04/11 09:00
CRDT- 2005/08/02 09:00
PHST- 2004/09/16 00:00 [received]
PHST- 2004/12/14 00:00 [revised]
PHST- 2005/05/27 00:00 [accepted]
PHST- 2005/08/02 09:00 [pubmed]
PHST- 2006/04/11 09:00 [medline]
PHST- 2005/08/02 09:00 [entrez]
AID - S0045-6535(05)00763-0 [pii]
AID - 10.1016/j.chemosphere.2005.05.043 [doi]
PST - ppublish
SO  - Chemosphere. 2006 Feb;62(7):1033-42. doi: 10.1016/j.chemosphere.2005.05.043. Epub 
      2005 Aug 1.