PMID- 16061149
OWN - NLM
STAT- MEDLINE
DCOM- 20051013
LR  - 20061115
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 19
IP  - 5
DP  - 2005 Sep
TI  - Muscle damage is linked to cytokine changes following a 160-km race.
PG  - 398-403
AB  - Muscle damage and perceived soreness following the 160-km Western States 
      Endurance Run were related to changes in plasma cytokines and use of nonsteroidal 
      anti-inflammatory drugs (NSAIDS). Subjects included 60 ultramarathoners 
      (mean+/-SE, age 45.3 +/- 1.1 years) who finished the race in under 30 h (26.3 +/- 
      0.4 h). Blood samples were collected the morning prior to and immediately 
      following the race, and subjects recorded muscle soreness during the week 
      following the race using a 10-point Likert scale (DOMS). Seven plasma cytokines 
      were measured including IL-6, IL-10, IL-8, IL-1ra, granulocyte colony-stimulating 
      factor (G-CSF), monocyte chemotactic protein 1 (MCP-1), and macrophage 
      inflammatory protein 1beta (MIP-1beta). Cytokine changes were compared between 
      NSAID users and nonusers, and correlated with creatine phosphokinase (CPK) and 
      DOMS. Significant increases were measured for all seven cytokines, with the 
      greatest fold increases seen for IL-6 (125x), IL-10 (24x), and G-CSF (12x). CPK 
      was correlated with changes in IL-6, G-CSF, IL-10, IL-1ra, and MCP-1 (r = 
      .49-.68), (P < .001), but not IL-8 or MIP-1beta. DOMS averaged 7.1 +/- 0.3 the 
      day after the race, and 5.0 +/- 0.3, 2.5 +/- 0.2, and 1.6 +/- 0.1 3 days, 5 days, 
      and 7 days post-race, respectively, and each was correlated with CPK (r = 
      .40-.63, P < .001) and changes in IL-6, G-CSF, IL-10, and MCP-1 (r = .28-.77, P < 
      .05). A comparison of NSAID users (72% of athletes) and nonusers showed no 
      differences in CPK or DOMS, but did reveal greater increases in five of seven 
      cytokines in the NSAID users (P < .05). In conclusion, muscle damage in athletes 
      competing in a 160-km race was significantly correlated with post-race DOMS and 
      increases in five of seven cytokines. NSAID users did not experience a reduction 
      in muscle damage or DOMS, but did have higher post-race plasma levels in five of 
      seven cytokines.
FAU - Nieman, David C
AU  - Nieman DC
AD  - Department of Health, Leisure, and Exercise Science, Fischer Hamilton/Nycom 
      Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA. 
      niemandc@appstate.edu
FAU - Dumke, Charles L
AU  - Dumke CL
FAU - Henson, Dru A
AU  - Henson DA
FAU - McAnulty, Steven R
AU  - McAnulty SR
FAU - Gross, Sarah J
AU  - Gross SJ
FAU - Lind, Robert H
AU  - Lind RH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cytokines)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Blood Cell Count
MH  - Blood Volume/physiology
MH  - Body Composition/physiology
MH  - Creatine Kinase/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Lymphocyte Subsets
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*metabolism/*pathology
MH  - Physical Endurance/*physiology
MH  - Running/*physiology
EDAT- 2005/08/03 09:00
MHDA- 2005/10/14 09:00
CRDT- 2005/08/03 09:00
PHST- 2005/02/03 00:00 [received]
PHST- 2005/03/04 00:00 [revised]
PHST- 2005/03/14 00:00 [accepted]
PHST- 2005/08/03 09:00 [pubmed]
PHST- 2005/10/14 09:00 [medline]
PHST- 2005/08/03 09:00 [entrez]
AID - S0889-1591(05)00053-X [pii]
AID - 10.1016/j.bbi.2005.03.008 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2005 Sep;19(5):398-403. doi: 10.1016/j.bbi.2005.03.008.