PMID- 16075463
OWN - NLM
STAT- MEDLINE
DCOM- 20051122
LR  - 20071115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 44
IP  - 3
DP  - 2005 Nov
TI  - BCL6 alternative translocation breakpoint cluster region associated with 
      follicular lymphoma grade 3B.
PG  - 301-4
AB  - Translocations involving band 3q27, affecting the major breakpoint region (MBR) 
      of BCL6, are common in diffuse large B-cell lymphomas (DLBCLs). Recent data 
      suggest an alternative breakpoint cluster region (ABR) located between 245 and 
      285 kb 5' of BCL6, which might be associated with Follicular Lymphoma (FL). Ten 
      DLBCLs and 9 FLs grade 3B with cytogenetic rearrangements at 3q27 were studied by 
      fluorescence in situ hybridization (FISH) to discriminate between breakpoints at 
      the ABR and MBR. Eight DLBCLs contained a breakpoint in the MBR, and 6 FL grade 
      3B (FL3B) cases contained a breakpoint in the ABR. No specific chromosomal 
      partners could be identified in both groups. Previously published data have 
      suggested that FL3B cases with 3q27 aberrations are closely related to the 
      majority of DLBCLs of germinal center cell origin. However, our findings suggest 
      that the mechanism of 3q27 rearrangement in FL3B cases is similar to the 
      mechanism in follicular lymphomas grade 1,2, and 3A cases.
CI  - (c) 2005 Wiley-Liss, Inc.
FAU - Bosga-Bouwer, Anneke G
AU  - Bosga-Bouwer AG
AD  - Department of Genetics, University Medical Center Groningen, University of 
      Groningen, Ant. Deusinglaan 4, AW 9713 Groningen, The Netherlands. 
      A.G.Bosga-Bouwer@medgen.umcg.nl
FAU - Haralambieva, Eugenia
AU  - Haralambieva E
FAU - Booman, Marije
AU  - Booman M
FAU - Boonstra, Ronald
AU  - Boonstra R
FAU - van den Berg, Anke
AU  - van den Berg A
FAU - Schuuring, Ed
AU  - Schuuring E
FAU - van den Berg, Eva
AU  - van den Berg E
FAU - Kluin, Philip
AU  - Kluin P
FAU - Poppema, Sibrand
AU  - Poppema S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Chromosomes, Human, Pair 14/genetics
MH  - *Chromosomes, Human, Pair 3
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Follicular/classification/*genetics/pathology
MH  - Lymphoma, Large B-Cell, Diffuse/genetics/pathology
MH  - Translocation, Genetic/*genetics
EDAT- 2005/08/03 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/03 09:00
PHST- 2005/08/03 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/03 09:00 [entrez]
AID - 10.1002/gcc.20246 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2005 Nov;44(3):301-4. doi: 10.1002/gcc.20246.