PMID- 16075976
OWN - NLM
STAT- MEDLINE
DCOM- 20060804
LR  - 20140625
VI  - 19
IP  - 9
DP  - 2005 May
TI  - [Expression of Skp2 and p27 proteins in laryngeal squamous cell carcinoma and 
      their significances].
PG  - 409-11
AB  - OBJECTIVE: To investigate the expression of Skp2 and p27 and their association 
      with clinical, histologic characteristics and prognosis in laryngeal squamous 
      cell carcinoma (LSCC), the correlation between expression of Skp2 and p27 in 
      LSCC. METHOD: Skp2 protein and p27 protein were examined by using 
      immunohistochemical SP staining method in 20 cases of normal laryngeal tissues 
      (NLT), 27 cases of laryngeal precancerous lesion (LPL) and 27 cases of LSCC. 
      RESULT: The positive rate of Skp2 in NLT, LPL and LSCC were 10.00% (2/20), 37.04% 
      (10/27) and 41.43% (29/70), respectively. The positive rates in the last two 
      groups were higher than the first one. The Skp2 protein expression in LSCC was 
      positively associated with the clinical stage and lymph node metastasis. The 
      positive rate of p27 protein in NLT and LSCC were 85.00% (17/20) and 48.57% 
      (34/70), respectively, and significant difference was found between two groups. 
      The p27 protein expression was inversely associated with lymph node metastasis. 
      Skp2 was inversely associated-with expression of p27 in LSCC. The survival rate 
      of patients with both Skp2 positive expression and negative expression of p27 was 
      significantly lower than that of other cases. CONCLUSION: Skp2 expression might 
      play an important role in the development and progression of LSCC via 
      cyclin-depended kinase inhibitor p27 proteolysis, and the combined examination of 
      Skp2 and p27 expression have a great significance in estimating prognosis of 
      patients with LSCC.
FAU - Li, Hui
AU  - Li H
AD  - Department of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, China. lihui5100@sina
FAU - Jiang, Xiaoqing
AU  - Jiang X
FAU - Zhou, Xuhong
AU  - Zhou X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (S-Phase Kinase-Associated Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - Cyclin-Dependent Kinase Inhibitor p27/*biosynthesis
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - S-Phase Kinase-Associated Proteins/*biosynthesis
EDAT- 2005/08/04 09:00
MHDA- 2006/08/05 09:00
CRDT- 2005/08/04 09:00
PHST- 2005/08/04 09:00 [pubmed]
PHST- 2006/08/05 09:00 [medline]
PHST- 2005/08/04 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 May;19(9):409-11.