PMID- 16075977
OWN - NLM
STAT- MEDLINE
DCOM- 20060804
LR  - 20181201
VI  - 19
IP  - 9
DP  - 2005 May
TI  - [Expression and significance of PTEN and Survivin between the primary foci and 
      the lymph node metastases foci of laryngeal squamous cell carcinoma].
PG  - 412-4, 416
AB  - OBJECTIVE: To investigate the molecular difference and significance between the 
      primary foci and metastases foci of laryngeal squamous cell carcinoma (LSCC). 
      METHOD: Tissues of 18 cases of positive lymph node metastases (N+) LSCC were 
      detected by using SP method. The LSCC primary foci and metastases foci and 
      negative metastases lymph nodes were included, 22 cases of vocal cord polyp (VCP) 
      were regarded as control. expression of PTEN and Survivin were evaluated by SP 
      immunohistochemistry. RESULT: Expression of neither PTEN nor Survivin were 
      positive in negative nodes. The positive rates of PTEN in LSCC, N+, VCP were 
      94.4% (17/18), 94.4% (17/18) and 95.5% (21/22) respectively, there were no 
      significant difference among them (P>0.05). But the expression degree were more 
      powerful in N+ than in the LSCC (P<0.05). There was no expression of Survivin in 
      VCP. The positive rates of Survivin in LSCC and N+ were 55.5% (10/18), 50.0% 
      (9/18), the difference were significant (P<0.01); but between LSCC and N+, 
      neither the positive rate nor the expression degree had significant difference 
      (P>0.05). CONCLUSIONS: There were differences between the LSCC primary foci and 
      the lymph node metastases foci in molecular level probably.
FAU - He, Long
AU  - He L
AD  - Department of Otorhinolaryngology, the First Affiliated Hospital of Jinan 
      University, Guangzhou, 510630, China. helong@126.com
FAU - Wang, Jiqun
AU  - Wang J
FAU - Shan, Yanchun
AU  - Shan Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Microtubule-Associated Proteins/*biosynthesis
MH  - Middle Aged
MH  - Neck
MH  - Neoplasm Proteins/*biosynthesis
MH  - PTEN Phosphohydrolase/*biosynthesis
MH  - Survivin
EDAT- 2005/08/04 09:00
MHDA- 2006/08/05 09:00
CRDT- 2005/08/04 09:00
PHST- 2005/08/04 09:00 [pubmed]
PHST- 2006/08/05 09:00 [medline]
PHST- 2005/08/04 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 May;19(9):412-4, 416.