PMID- 16076032
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20061115
IS  - 0171-2985 (Print)
IS  - 0171-2985 (Linking)
VI  - 210
IP  - 1
DP  - 2005
TI  - Intra-bone marrow-bone marrow transplantation facilitates hemopoietic recovery 
      including dendritic cells.
PG  - 33-42
AB  - In this report, we provide evidence using a serial bone marrow transplantation 
      (BMT) protocol that intra-bone marrow (IBM)-BMT (IBM-BMT) can efficiently 
      reconstitute the hemopoietic system with cells of donor origin, in contrast to 
      conventional intravenous (IV)-BMT (IV-BMT). Furthermore, the hematolymphoid 
      system of secondary recipients that had received bone marrow cells (BMCs) from 
      primary recipients treated with IBM-BMT recovered earlier than that of the 
      secondary recipients of BMCs from primary recipients treated with IV-BMT. This 
      was the case when the Lin-/c-kit+ progenitor cells of the secondary and tertiary 
      recipients were examined. These findings indicate that IBM-BMT can facilitate the 
      development of not only cells of various lineages but also the effective 
      generation and, more importantly, the maintenance of the progenitor cells. 
      Furthermore, we show that IBM-BMT can reconstitute the dendritic cell (DC) 
      subsets (myeloid and lymphoid DCs), which are critical for the initiation of both 
      adaptive and innate immune responses. The frequency of both myeloid and lymphoid 
      DC subsets was approximately equal to that of normal age-matched untreated 
      controls and, after second and third BMT, this ratio was close to that observed 
      in the normal controls. However, the lymphoid DCs were clearly reduced in the 
      secondary and tertiary recipients of BMCs from mice that had received IV-BMT. 
      Therefore, the development of DC subsets is also normally maintained in the 
      IBM-BMT group.
FAU - Baba, Susumu
AU  - Baba S
AD  - First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, 
      Japan.
FAU - Inaba, Muneo
AU  - Inaba M
FAU - Iwai, Hiroshi
AU  - Iwai H
FAU - Taira, Mitsuru
AU  - Taira M
FAU - Takada, Keizo
AU  - Takada K
FAU - Hisha, Hiroko
AU  - Hisha H
FAU - Yamashita, Toshio
AU  - Yamashita T
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/methods/*physiology
MH  - Dendritic Cells/*cytology
MH  - Graft vs Host Disease/immunology
MH  - Hematopoietic Stem Cells/physiology
MH  - Mice
MH  - Mice, Congenic
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Spleen/cytology
MH  - Transplantation Conditioning
EDAT- 2005/08/04 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/08/04 09:00
PHST- 2005/08/04 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/08/04 09:00 [entrez]
AID - S0171-2985(05)00061-6 [pii]
AID - 10.1016/j.imbio.2005.02.005 [doi]
PST - ppublish
SO  - Immunobiology. 2005;210(1):33-42. doi: 10.1016/j.imbio.2005.02.005.