PMID- 16076294
OWN - NLM
STAT- MEDLINE
DCOM- 20051103
LR  - 20061115
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 60
IP  - 9
DP  - 2005 Sep
TI  - Allergy and cancer.
PG  - 1116-20
AB  - BACKGROUND: Conflicting results have provided support for two distinct and 
      contradictory hypotheses: (i) allergy has a protective effect against cancer by 
      enhanced immune surveillance, and (ii) allergy is associated with an increased 
      risk of cancer by chronic immune stimulation. We therefore aimed us to perform a 
      large epidemiological study with a defined allergic disease cohort. METHODS: 
      During the years 1988-2000, 70 136 patients tested for total serum immunoglobulin 
      E (IgE) and 57 815 tested with Phadiatop for diagnosing allergic disease at 
      Karolinska University Hospital, Stockholm, Sweden, were linked with the Swedish 
      Cancer Registry for a virtually complete follow up with regard to cancer. 
      FINDINGS: The total number of observed cancers was normal in the total serum 
      IgE-cohort; standardized incidence ratio (SIR) = 0.98 (95% CI: 0.92-1.04) and in 
      the Phadiatop-cohort: SIR = 0.99 (0.92-1.06) independent of the level of IgE and 
      positive or negative Phadiatop. Specific analysis was done for cancer of the 
      lung, cervix, pancreas, lymphoma, and nonmelanoma skin cancer. None of these 
      forms of cancer had increased risks. INTERPRETATION: The study does not support 
      the hypothesis that allergy has a protective effect against cancer, nor does it 
      support an increased risk.
FAU - Lindelof, B
AU  - Lindelof B
AD  - Unit of Dermatology and Venereology, Karolinska University Hospital and 
      Institute, Stockholm, Sweden.
FAU - Granath, F
AU  - Granath F
FAU - Tengvall-Linder, M
AU  - Tengvall-Linder M
FAU - Ekbom, A
AU  - Ekbom A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Allergy. 2005 Sep;60(9):1095-7. PMID: 16076291
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Epidemiologic Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/complications/*immunology
MH  - Immune Tolerance/immunology
MH  - Immunoglobulin E/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/complications/*immunology
MH  - Sweden
EDAT- 2005/08/04 09:00
MHDA- 2005/11/04 09:00
CRDT- 2005/08/04 09:00
PHST- 2005/08/04 09:00 [pubmed]
PHST- 2005/11/04 09:00 [medline]
PHST- 2005/08/04 09:00 [entrez]
AID - ALL808 [pii]
AID - 10.1111/j.1398-9995.2005.00808.x [doi]
PST - ppublish
SO  - Allergy. 2005 Sep;60(9):1116-20. doi: 10.1111/j.1398-9995.2005.00808.x.