PMID- 16079989
OWN - NLM
STAT- MEDLINE
DCOM- 20060824
LR  - 20151119
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 80
IP  - 2
DP  - 2006 Feb
TI  - Diminished embryonic movements of developing embryo by direct exposure of 
      sidestream whole smoke solutions.
PG  - 107-14
AB  - Embryonic movements (EM) are considered to be the first sign of life and 
      cigarette smoking during pregnancy has been linked to affect EM. Exposure to 
      sidestream smoke, produced from the emissions of a smoldering cigarette, may 
      result in poor pregnancy outcome and increased risk of serious perinatal 
      morbidity and mortality. In this study, the chicken embryo bioassay was used to 
      systematically assess the effects of short-term exposure to sidestream whole 
      smoke solutions (SSWSS) on EM, recorded in real time by a video camera for 60 min 
      and each EM was counted for every 3-min interval. Application of different types 
      of SSWSS to the embryos caused significant changes in all types of EM from 15 to 
      18 min of recording time. Extensive reduction (P<0.001) and some time complete 
      stoppage of swing-like movements and whole-body movements were observed in almost 
      all treated embryos. Our data clearly link between exposure of SSWSS and 
      substantial decrease in EM. It is unclear whether nicotine and/or other 
      ingredients present in sidestream smoke are responsible for these alterations in 
      EM. This article provides an outline of the relevance of SSWSS on EM for 
      evolutionary developmental biology and this assay can be used to investigate the 
      complex mixtures with regard to their effects on EM.
FAU - Ejaz, Sohail
AU  - Ejaz S
AD  - Biosafety Research Institute, Chonbuk National University, Jeonju, South Korea.
FAU - Woong, Lim Chae
AU  - Woong LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050804
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Tobacco Smoke Pollution)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Chick Embryo
MH  - Embryonic Development/*drug effects
MH  - Movement/*drug effects
MH  - Nicotine/adverse effects
MH  - Tobacco Smoke Pollution/*adverse effects
MH  - Videotape Recording
EDAT- 2005/08/05 09:00
MHDA- 2006/08/25 09:00
CRDT- 2005/08/05 09:00
PHST- 2005/02/21 00:00 [received]
PHST- 2005/06/23 00:00 [accepted]
PHST- 2005/08/05 09:00 [pubmed]
PHST- 2006/08/25 09:00 [medline]
PHST- 2005/08/05 09:00 [entrez]
AID - 10.1007/s00204-005-0012-x [doi]
PST - ppublish
SO  - Arch Toxicol. 2006 Feb;80(2):107-14. doi: 10.1007/s00204-005-0012-x. Epub 2005 
      Aug 4.