PMID- 16080555
OWN - NLM
STAT- MEDLINE
DCOM- 20050920
LR  - 20050805
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 25
IP  - 4
DP  - 2005 Jul-Aug
TI  - Impact of cytogenetic and molecular cytogenetic studies on hematologic 
      malignancies.
PG  - 2979-83
AB  - Conventional cytogenetic analysis of chromosome abnormalities in hematologic 
      malignancies is hampered by the low mitotic index and poor quality of metaphases. 
      A range of techniques based on fluorescence in situ hybridization (FISH) has 
      greatly enhanced the identification of non-random translocations and deletions, 
      pinpointing regions which contain genes involved in leukemogenesis. One of the 
      main advantages of FISH is its ability to use non-dividing interphase cells as 
      DNA targets, enabling the screening of large numbers of cells and providing 
      access to a variety of cells with different hematopoetic activity. Furthermore, 
      multicolor FISH (SKY, M-FISH and CGH microarrays) combines the screening 
      potential of cytogenetics with the accuracy of molecular genetics, allowing the 
      visualization of the entire human genome in 24 different colors.
FAU - Kolialexi, A
AU  - Kolialexi A
AD  - Medical Genetics, University of Athens School of Medicine, Athens, Greece. 
      akolialexi@cc.uoa.gr
FAU - Tsangaris, G Th
AU  - Tsangaris GT
FAU - Kitsiou, S
AU  - Kitsiou S
FAU - Kanavakis, E
AU  - Kanavakis E
FAU - Mavrou, A
AU  - Mavrou A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosome Painting
MH  - Cytogenetic Analysis/*methods
MH  - Hematologic Neoplasms/diagnosis/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Nucleic Acid Hybridization
RF  - 56
EDAT- 2005/08/06 09:00
MHDA- 2005/09/21 09:00
CRDT- 2005/08/06 09:00
PHST- 2005/08/06 09:00 [pubmed]
PHST- 2005/09/21 09:00 [medline]
PHST- 2005/08/06 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2005 Jul-Aug;25(4):2979-83.