PMID- 16081486
OWN - NLM
STAT- MEDLINE
DCOM- 20051227
LR  - 20181113
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 568
IP  - Pt 2
DP  - 2005 Oct 15
TI  - The effect of low protein diet in pregnancy on the development of brain 
      metabolism in rat offspring.
PG  - 553-8
AB  - The effect of maternal low protein diet in pregnancy on the function of offspring 
      cerebral cytochrome c oxidase (CcO) was investigated in vitro immediately before 
      and after birth, using fetal and neonatal rat pup forebrain tissue. Pregnant rat 
      dams were fed either a control (C, 18% casein n = 22) or low protein (LP, 9% 
      casein n = 14) diet. Cerebral tissues were harvested from pups the day before 
      (E21) and after (P1) birth. A Clarke electrode chamber was used to determine O(2) 
      consumption in brain tissue homogenate, under baseline conditions with and 
      without the mitochondrial electron transport chain inhibitor myxothiazol and in 
      the presence of incremental doses of the electron donor 
      N',N',N',N'-tetramethyl-p-phenylenediamide (TMPD) with myxothiazol. Maximal 
      stimulated CcO activity was less in LP versus C pups at both E21 (P < 0.001) and 
      P1 (P < 0.05). At E21 only, sensitivity to electron flux (pEC(50)) was greater (P 
      < 0.001) in LP compared to C offspring. In addition, was reduced and pEC(50) was 
      greater after birth (i.e. P1 versus E21) in C (P < 0.001) but not in LP pups. 
      This is the first report of the effects of maternal dietary imbalance in 
      pregnancy on offspring cerebral metabolic function. The effects may form part of 
      a developmental adaptive response to reduce energy consumption and promote 
      perinatal survival, or to confer advantage in a postnatal environment predicted 
      to be nutritionally poor.
FAU - Gallagher, E A L
AU  - Gallagher EA
AD  - Centre for Developmental Origins of Health and Disease, University of 
      Southampton, 887F Princess Anne Hospital, Hants, UK.
FAU - Newman, J P
AU  - Newman JP
FAU - Green, L R
AU  - Green LR
FAU - Hanson, M A
AU  - Hanson MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050804
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/embryology/growth & development/*metabolism
MH  - *Diet, Protein-Restricted
MH  - Electron Transport Complex IV/*metabolism
MH  - Female
MH  - Fetus
MH  - Male
MH  - Oxygen Consumption
MH  - Pregnancy
MH  - Protein Deficiency/*physiopathology
MH  - Rats
MH  - Rats, Wistar
PMC - PMC1474740
EDAT- 2005/08/06 09:00
MHDA- 2005/12/28 09:00
PMCR- 2006/10/15
CRDT- 2005/08/06 09:00
PHST- 2005/08/06 09:00 [pubmed]
PHST- 2005/12/28 09:00 [medline]
PHST- 2005/08/06 09:00 [entrez]
PHST- 2006/10/15 00:00 [pmc-release]
AID - jphysiol.2005.092825 [pii]
AID - 10.1113/jphysiol.2005.092825 [doi]
PST - ppublish
SO  - J Physiol. 2005 Oct 15;568(Pt 2):553-8. doi: 10.1113/jphysiol.2005.092825. Epub 
      2005 Aug 4.