PMID- 16083866
OWN - NLM
STAT- MEDLINE
DCOM- 20051221
LR  - 20151119
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1054
IP  - 2
DP  - 2005 Aug 30
TI  - Tyrosine administration does not affect desipramine-induced dopamine levels as 
      measured in vivo in prefrontal cortex.
PG  - 203-6
AB  - Using in vivo microdialysis, we examined whether tyrosine administration would 
      potentiate the desipramine (DMI)-induced elevation of medial prefrontal cortex 
      (MPFC) dopamine (DA) levels. DMI (10 or 20 mg/kg IP) increased MPFC DA levels but 
      not DOPA accumulation. Tyrosine (12.5-100 mug/ml) administered by reverse 
      microdialysis did not affect DMI-induced MPFC DA levels. The data support our 
      hypothesis that DA synthesis must be significantly increased in order for 
      administered tyrosine to increase extracellular DA levels.
FAU - Bongiovanni, Rodolfo
AU  - Bongiovanni R
AD  - Louis Stokes Department of Veterans Affairs Medical Center, Case Western Reserve 
      University, 10000 Brecksville Road, Brecksville, OH 44141, USA.
FAU - Kirkbride, Bobbi
AU  - Kirkbride B
FAU - Walmire, Peter
AU  - Walmire P
FAU - Jaskiw, George E
AU  - Jaskiw GE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Hydrazines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 42HK56048U (Tyrosine)
RN  - A27K5Q85R2 (3-hydroxybenzylhydrazine)
RN  - TG537D343B (Desipramine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Desipramine/*pharmacology
MH  - Dopamine/*metabolism
MH  - Drug Interactions
MH  - Enzyme Inhibitors/*pharmacology
MH  - Hydrazines/pharmacology
MH  - Male
MH  - Microdialysis/methods
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Tyrosine/*administration & dosage
EDAT- 2005/08/09 09:00
MHDA- 2005/12/22 09:00
CRDT- 2005/08/09 09:00
PHST- 2005/03/29 00:00 [received]
PHST- 2005/06/24 00:00 [revised]
PHST- 2005/06/28 00:00 [accepted]
PHST- 2005/08/09 09:00 [pubmed]
PHST- 2005/12/22 09:00 [medline]
PHST- 2005/08/09 09:00 [entrez]
AID - S0006-8993(05)00998-4 [pii]
AID - 10.1016/j.brainres.2005.06.070 [doi]
PST - ppublish
SO  - Brain Res. 2005 Aug 30;1054(2):203-6. doi: 10.1016/j.brainres.2005.06.070.