PMID- 16083971
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20151119
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 167
IP  - 1-2
DP  - 2005 Oct
TI  - Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: 
      reversal by glatiramer acetate.
PG  - 215-8
AB  - Neuronal growth factors may exert a neuroprotective effect in multiple sclerosis 
      (MS). We found reduced levels of brain-derived neurotrophic factors (BDNF) in the 
      serum and CSF of relapsing-remitting MS patients, which was reversed by therapy 
      with glatiramer acetate. BDNF may play a protective role in MS, and 
      immunomodulation therapy, such as with glatiramer acetate, may enhance the action 
      this mechanism.
FAU - Azoulay, David
AU  - Azoulay D
AD  - Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
FAU - Vachapova, Veronika
AU  - Vachapova V
FAU - Shihman, Boris
AU  - Shihman B
FAU - Miler, Ariel
AU  - Miler A
FAU - Karni, Arnon
AU  - Karni A
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Peptides)
RN  - 5M691HL4BO (Glatiramer Acetate)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood/cerebrospinal fluid
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - Glatiramer Acetate
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*blood/cerebrospinal fluid/*drug therapy
MH  - Peptides/*therapeutic use
EDAT- 2005/08/09 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/09 09:00
PHST- 2005/04/04 00:00 [received]
PHST- 2005/07/06 00:00 [accepted]
PHST- 2005/08/09 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/09 09:00 [entrez]
AID - S0165-5728(05)00276-6 [pii]
AID - 10.1016/j.jneuroim.2005.07.001 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2005 Oct;167(1-2):215-8. doi: 10.1016/j.jneuroim.2005.07.001.