PMID- 16084892
OWN - NLM
STAT- MEDLINE
DCOM- 20051227
LR  - 20050808
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 84
IP  - 2
DP  - 2005 Aug
TI  - Protective effect of vascular endothelial growth factor on histologic changes in 
      testicular ischemia-reperfusion injury.
PG  - 468-73
AB  - OBJECTIVE: To evaluate the efficacy of vascular endothelial growth factor (VEGF) 
      on long-term histologic damage in testicular ischemia-reperfusion injury. DESIGN: 
      Controlled experimental study using rats. SETTING: University of Mersin School of 
      Medicine, Mersin, Turkey. ANIMAL(S): Sixteen adult male Wistar rats. 
      INTERVENTION(S): Five rats underwent 2 hours of testicular torsion. Six rats 
      received VEGF injection into the testis before detorsion. Five rats underwent 
      sham operation. MAIN OUTCOME MEASURE(S): Mean seminiferous tubular diameter 
      (MSTD), germinal epithelial cell thickness (GECT), mean testicular biopsy score 
      (MTBS), and apoptosis (caspase-3-positive cells). RESULT(S): Testicular 
      torsion-detorsion caused a significant decrease in MSTD, GECT, and MTBS and a 
      significant increase in the mean value of caspase-3-positive cells in ipsilateral 
      testes but not in the contralateral testes. The MSTD, GECT, and MTBS of the 
      ipsilateral testes were significantly higher in the group treated with VEGF than 
      in the torsion-detorsion group. The animals treated with VEGF had a significant 
      decrease in the mean value of ipsilateral testicular caspase-3-positive cells 
      compared with the torsion-detorsion group. CONCLUSION(S): Vascular endothelial 
      growth factor might have a role in testicular damage caused by 
      ischemia-reperfusion. Administering VEGF before reperfusion might have the 
      potential to decrease the long-term histologic damage after testicular torsion.
FAU - Tunckiran, Ahmet
AU  - Tunckiran A
AD  - Department of Urology, University of Mersin School of Medicine, Mersin, Turkey.
FAU - Cayan, Selahittin
AU  - Cayan S
FAU - Bozlu, Murat
AU  - Bozlu M
FAU - Yilmaz, Necat
AU  - Yilmaz N
FAU - Acar, Deniz
AU  - Acar D
FAU - Akbay, Erdem
AU  - Akbay E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Animals
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/*metabolism/*pathology/therapy
MH  - Spermatic Cord Torsion/*metabolism/*pathology/physiopathology/prevention & 
      control
MH  - Testis/blood supply/*pathology/physiology
MH  - Vascular Endothelial Growth Factor A/administration & dosage/*physiology
EDAT- 2005/08/09 09:00
MHDA- 2005/12/28 09:00
CRDT- 2005/08/09 09:00
PHST- 2004/10/13 00:00 [received]
PHST- 2005/01/14 00:00 [revised]
PHST- 2005/01/14 00:00 [accepted]
PHST- 2005/08/09 09:00 [pubmed]
PHST- 2005/12/28 09:00 [medline]
PHST- 2005/08/09 09:00 [entrez]
AID - S0015-0282(05)01034-4 [pii]
AID - 10.1016/j.fertnstert.2005.01.144 [doi]
PST - ppublish
SO  - Fertil Steril. 2005 Aug;84(2):468-73. doi: 10.1016/j.fertnstert.2005.01.144.