PMID- 16086285
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20050808
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 22
IP  - 4
DP  - 2005 Aug
TI  - [Marker chromosome analysis in Chinese patients with Turner syndrome by 
      fluorescence in situ hybridization].
PG  - 435-7
AB  - OBJECTIVE: To identify the origin of marker chromosome of patients with Turner 
      syndrome, and to provide the information for genetic counseling and treatment. 
      METHODS: The karyotypes of 32 patients with Turner syndrome from 2001 to 2003 at 
      the Center for Diagnosis of Genetic Metabolic Diseases were reviewed. Metaphase 
      chromosome analyses of peripheral blood lymphocytes, G-band and C-band were 
      performed using standard methods. Fluorescence in situ hybridization (FISH) was 
      performed to identify the origin of marker chromosome by using two probes: 
      sex-determining region Y (SRY) for band region Yp11.3 and chromosome enumeration 
      probe for X(CEPX) for band region Xp11.1-q11.1. RESULTS: 3/32(9.4%) patients with 
      Turner syndrome had marker chromosome, the karyotype being 45,X/46,X,mar. Among 
      the 3 marker chromosomes, 2 originated from chromosome X or Y, as identified by 
      the FISH. The origin of the third marker chromosome could not be identified by 
      CEPX and SRY probes. CONCLUSION: The presence of a marker chromosome in Turner 
      syndrome generally implicates a sex chromosome origin. It may also originate from 
      a non-sex chromosome. Therefore, it is necessary to apply X and Y probes 
      simultaneously for marker chromosome detection in Turner patients with monosomy 
      X.
FAU - Liang, Yan
AU  - Liang Y
AD  - Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030 PR China.
FAU - Luo, Xiao-ping
AU  - Luo XP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adolescent
MH  - Chromosome Banding
MH  - Chromosomes, Human, X/genetics
MH  - Chromosomes, Human, Y/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping
MH  - Turner Syndrome/diagnosis/*genetics
EDAT- 2005/08/09 09:00
MHDA- 2009/03/20 09:00
CRDT- 2005/08/09 09:00
PHST- 2005/08/09 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2005/08/09 09:00 [entrez]
AID - 940622106 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug;22(4):435-7.