PMID- 16086889
OWN - NLM
STAT- MEDLINE
DCOM- 20070216
LR  - 20150313
VI  - 24
IP  - 8
DP  - 2005 Aug
TI  - [Correlation of bone marrow stromal cells to leukemia and its research 
      advancement in gene therapy for leukemia].
PG  - 1033-6
AB  - Bone marrow stromal cells (BMSCs) have a pluripotent characteristic, and can be 
      readily isolated and expanded in vitro. After in vivo transplantation, BMSCs can 
      home to blood marrow, and survive for a long time by self-renewing. They can 
      influence the biological characteristics of leukemia cells from several aspects, 
      and participate in the outbreak process and pathologic process of leukemia. BMSCs 
      with normal functions have direct antitumur effects on leukemic cells. They can 
      regulate the immunity remarkably. Genetically engineered BMSCs can deliver target 
      therapeutic proteins over sufficient time after in vivo transplantation. Thus, 
      BMSCs are considered to be an ideal therapeutic cell vehicle and target cells in 
      the gene therapy for leukemia. Interferons, a cytokines family, are capable of 
      producing multiplex biological effects, and have remarkable curative effects on 
      hair cell leukemia and chronic myelogenous leukemia. Here we reviewed the 
      possibility and perspective of molecular target therapy for leukemia by 
      interferons-modified BMSCs.
FAU - Li, Xiao-Qing
AU  - Li XQ
AD  - Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen 
      University, Guangzhou, Guangdong, P. R. China.
FAU - Lu, Yue
AU  - Lu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Ai Zheng
JT  - Ai zheng = Aizheng = Chinese journal of cancer
JID - 9424852
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology/physiology
MH  - Cell Differentiation
MH  - *Genetic Therapy
MH  - Humans
MH  - Leukemia/pathology/*therapy
MH  - Neovascularization, Pathologic
MH  - Stromal Cells/*cytology/physiology
RF  - 25
EDAT- 2005/08/10 09:00
MHDA- 2007/02/17 09:00
CRDT- 2005/08/10 09:00
PHST- 2005/08/10 09:00 [pubmed]
PHST- 2007/02/17 09:00 [medline]
PHST- 2005/08/10 09:00 [entrez]
AID - 1000467X2005081033 [pii]
PST - ppublish
SO  - Ai Zheng. 2005 Aug;24(8):1033-6.