PMID- 16087133
OWN - NLM
STAT- MEDLINE
DCOM- 20051213
LR  - 20110608
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 7
IP  - 5
DP  - 2005 Aug
TI  - Semiquantitative histomorphometric analysis of myocardium following partial left 
      ventriculectomy: 1-year follow-up.
PG  - 763-7
AB  - BACKGROUND: Although partial left ventriculectomy (PLV) may have beneficial 
      clinical effects in patients with dilated cardiomyopathy (DCM), there are no 
      reports on effects of PLV on myocardial histology. The objective of this study 
      was to assess histological properties of the LV myocardium 1 year following PLV 
      as compared to histology at the time of the operation. METHODS: The study group 
      consisted of 15 consecutive PLV survivors, predominantly male (13/15), aged 
      45+/-12 years. Surgical specimens and endomyocardial biopsies, taken 12 months 
      postoperatively, were processed routinely and stained with Masson-trichrome. The 
      following morphometric parameters were assessed semiquantitavely: (1) degree of 
      hypertrophy and attenuation; (2) nuclear evidence of hypertrophy; (3) 
      myofibrillar volume fraction; (4) degree of degenerative vacuolar changes; and 
      (5) fibrosis volume fraction. RESULTS: Both New York Heart Association (NYHA) 
      functional class and ejection fraction (EF) improved 12 months following surgery 
      as compared to preoperative values (2.40+/-0.69 vs. 3.33+/-0.49, p<0.001, and 
      33.21+/-12.05% vs. 20.21+/-9.07%, p<0.001, respectively). Morphometric analysis 
      demonstrated postoperative decrease in the degree of attenuation as compared to 
      preoperative values (1.40+/-0.51 vs. 2.47+/-0.64, p<0.01), as well as a decrease 
      in fibrosis volume fraction (2.07+/-0.80 vs. 2.67+/-0.49, p<0.001) and nuclear 
      hypertrophy (1.27+/-0.46 vs. 1.67+/-0.62, p<0.05). On the other hand, 
      postoperative increase in myofibrillar volume fraction (1.87+/-0.61 vs. 
      1.40+/-0.61, p<0.01) was noted. CONCLUSION: One year postoperatively, PLV has 
      favourable effects on myocardial morphology that parallels improvement in the 
      patient's functional status and LV systolic function.
FAU - Vasiljevic, Jovan D
AU  - Vasiljevic JD
AD  - Institute of Pathology, Belgrade University School of Medicine, Dr. Subotica 1, 
      11000, Serbia and Montenegro. lole@beotel.yu
FAU - Otasevic, Petar
AU  - Otasevic P
FAU - Popovic, Zoran B
AU  - Popovic ZB
FAU - Neskovic, Aleksandar N
AU  - Neskovic AN
FAU - Vidakovic, Radoslav
AU  - Vidakovic R
FAU - Popovic, Zoran V
AU  - Popovic ZV
FAU - Radovancevic, Branislav
AU  - Radovancevic B
FAU - Frazier, O Howard
AU  - Frazier OH
FAU - Gradinac, Sinisa
AU  - Gradinac S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/physiopathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/*surgery
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Stroke Volume
MH  - Ventricular Function, Left
EDAT- 2005/08/10 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/08/10 09:00
PHST- 2003/12/17 00:00 [received]
PHST- 2004/07/07 00:00 [revised]
PHST- 2004/09/20 00:00 [accepted]
PHST- 2005/08/10 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/08/10 09:00 [entrez]
AID - S1388-9842(04)00254-5 [pii]
AID - 10.1016/j.ejheart.2004.09.016 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2005 Aug;7(5):763-7. doi: 10.1016/j.ejheart.2004.09.016.