PMID- 16087306
OWN - NLM
STAT- MEDLINE
DCOM- 20060503
LR  - 20171116
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 40
IP  - 11
DP  - 2005 Nov
TI  - Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune 
      system of non-human primates.
PG  - 884-93
AB  - Humanity has been obsessed with extending life span and reversing the aging 
      process throughout recorded history and this quest most likely preceded the 
      invention of the written word. The search for eternal youth has spurred holy wars 
      and precipitated the discovery of the new world (the 'Fountain of youth'). It 
      therefore comes as no surprise that an increasingly greater amount of research 
      effort is dedicated to improve our understanding of the aging process and finding 
      interventions to moderate its impact on health. Caloric restriction (CR) is the 
      only intervention in biology that consistently extends maximal and median life 
      span in a variety of short-lived species. Several theories to explain the 
      mechanisms of action of CR have been put forth, including the possibility that CR 
      acts by retarding immune senescence. The question remains, however, whether CR 
      will have the same beneficial impact on human aging, and, if so, how long does CR 
      need to last to produce beneficial effects. To address this question, several 
      groups initiated long-term studies in Rhesus macaques (RM) in the 1980s. Here, we 
      review published data describing the impact of CR on the aging immune system of 
      mice and primates, and discuss our unpublished data that delineate similarities 
      and differences in the effects of CR upon T cell aging and homeostasis between 
      these two models.
FAU - Nikolich-Zugich, Janko
AU  - Nikolich-Zugich J
AD  - Vaccine and Gene Therapy Institute and the Oregon National Primate Research 
      Center, Oregon Health & Science University, Beaverton, OR 97006, USA. 
      nikolich@ohsu.edu
FAU - Messaoudi, Ilhem
AU  - Messaoudi I
LA  - eng
GR  - U01 AG021384/AG/NIA NIH HHS/United States
GR  - AG21384/AG/NIA NIH HHS/United States
GR  - RR0163/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20050808
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Cell Proliferation
MH  - Cellular Senescence
MH  - Drosophila
MH  - Gene Expression Regulation
MH  - Immune System/*physiology
MH  - Macaca fascicularis
MH  - Mice
MH  - Models, Biological
MH  - Primates/*physiology
MH  - Research Design
MH  - Vaccination
RF  - 95
EDAT- 2005/08/10 09:00
MHDA- 2006/05/04 09:00
CRDT- 2005/08/10 09:00
PHST- 2005/05/23 00:00 [received]
PHST- 2005/06/28 00:00 [revised]
PHST- 2005/06/28 00:00 [accepted]
PHST- 2005/08/10 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2005/08/10 09:00 [entrez]
AID - S0531-5565(05)00118-X [pii]
AID - 10.1016/j.exger.2005.06.007 [doi]
PST - ppublish
SO  - Exp Gerontol. 2005 Nov;40(11):884-93. doi: 10.1016/j.exger.2005.06.007. Epub 2005 
      Aug 8.