PMID- 16088445
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20051005
LR  - 20050809
IS  - 1069-3424 (Print)
IS  - 1069-3424 (Linking)
VI  - 25
IP  - 1
DP  - 2004 Feb
TI  - Initiation of lung immunity: the afferent limb and the role of dendritic cells.
PG  - 11-20
AB  - The lung is the largest epithelial surface in the body and constitutes a major 
      portal of entry for microorganisms. Dendritic cells (DCs) are bone marrow-derived 
      cells that populate the respiratory tract from the nasal mucosa to the lung 
      pleura. DCs are dexterous cells playing a role in both the innate and the 
      adaptive immune responses. DCs can respond to dangers in the lung by immediately 
      generating protective cytokines that stimulate natural killer (NK) cells to 
      produce cytokines and kill targets. Direct (by pathogen recognition receptors) 
      and indirect (by inflammatory cytokines) recognition of the infectious agent can 
      also trigger signaling pathways in the DCs that activate an integrated 
      developmental program called maturation, which transforms DCs into efficient 
      antigen-presenting cells (APCs) for naive T cell stimulation. Furthermore, DCs 
      play a role in generating effector B cells in the lymph nodes draining the lung. 
      This review focuses on how DCs sense the health of the lung and translate 
      messages regarding the lung microenvironment to cells of the innate and adaptive 
      immune response to initiate effector functions to clear an invading microorganism 
      [T helper 1 (Th1) or Th2 response] or generate tolerance [T regulatory (Tr), 
      anergy, or deletion] to inhaled antigen when no danger is sensed.
FAU - Masten, Barbara J
AU  - Masten BJ
AD  - Department of Pathology, University of New Mexico, School of Medicine, 
      Albuquerque, New Mexico, USA. bmasten@salud.unm.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
EDAT- 2005/08/10 09:00
MHDA- 2005/08/10 09:01
CRDT- 2005/08/10 09:00
PHST- 2005/08/10 09:00 [pubmed]
PHST- 2005/08/10 09:01 [medline]
PHST- 2005/08/10 09:00 [entrez]
AID - 10.1055/s-2004-822301 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2004 Feb;25(1):11-20. doi: 10.1055/s-2004-822301.