PMID- 16091206
OWN - NLM
STAT- MEDLINE
DCOM- 20060120
LR  - 20220716
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 5
IP  - 5
DP  - 2005 Sep
TI  - The role of the FOXP3 transcription factor in the immune regulation of allergic 
      asthma.
PG  - 356-61
AB  - Unbalanced immune reactions against allergens are caused by Th2 cells, which are 
      the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. 
      Although Th2 cells are essential for allergy, they are not sufficient to cause 
      disease, because regulatory T cells (Tregs) control their activity and expansion. 
      Therefore, Tregs are assumed to play an important role not only in the 
      sensitization but also in established allergic disease under therapy. A key 
      factor of Tregs is FOXP3, which, upon expression, is sufficient to induce 
      regulatory T-cell phenotypes. The initiation and suppressive function of FOXP3 
      and Tregs in the context of allergic asthma are discussed in this review.
FAU - Schmidt-Weber, Carsten B
AU  - Schmidt-Weber CB
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), Obere Str. 22, CH-7270 
      Davos, Switzerland. carsten.schmidt-weber@siaf.unizh.ch
FAU - Blaser, Kurt
AU  - Blaser K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Asthma/etiology/*immunology/*metabolism
MH  - Forkhead Transcription Factors/*metabolism
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Immune System/*physiopathology
MH  - T-Lymphocytes, Regulatory
RF  - 59
EDAT- 2005/08/11 09:00
MHDA- 2006/01/21 09:00
CRDT- 2005/08/11 09:00
PHST- 2005/08/11 09:00 [pubmed]
PHST- 2006/01/21 09:00 [medline]
PHST- 2005/08/11 09:00 [entrez]
AID - 10.1007/s11882-005-0006-z [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2005 Sep;5(5):356-61. doi: 10.1007/s11882-005-0006-z.