PMID- 16091232
OWN - NLM
STAT- MEDLINE
DCOM- 20051125
LR  - 20191109
IS  - 1548-3568 (Print)
IS  - 1548-3568 (Linking)
VI  - 1
IP  - 3
DP  - 2004 Sep
TI  - Immune restoration inflammatory syndromes: apparently paradoxical clinical events 
      after the initiation of HAART.
PG  - 122-7
AB  - Immune reconstitution occurs after initiation of highly active antiretroviral 
      therapy in immunodeficient HIV-positive individuals. Unexpected deterioration of 
      inflammatory disease and atypical clinical features resembling symptoms of 
      autoimmune disease may arise. These atypical inflammatory disorders, synonymously 
      summarized as immune reconstitution syndrome, immune restoration disease, and 
      immune restoration inflammatory syndrome (IRIS), are caused by augmentation of 
      inflammation during immune reconstitution in an immunocompromised host. These 
      disorders have to be distinguished from intercurrent infection and rheumatic 
      disease, respectively. Treatment of IRIS consists of elements for both potential 
      differential diagnoses (ie, anti-inflammatory and immunosuppressive drugs, such 
      as in autoimmune disorders and antimicrobial chemotherapy, to decrease the burden 
      of pathogen, such as in infectious disease). Therefore, awareness for IRIS is of 
      increasing importance from a clinical point of view. However, diagnostic criteria 
      and standards of treatment are still preliminary.
FAU - Stoll, Matthias
AU  - Stoll M
AD  - Department Clinical Immunology, Medical School Hannover, Carl Neuberg Street 1, 
      D-30625 Hannover, Germany. stoll.matthias@mh-hannover.de
FAU - Schmidt, Reinhold E
AU  - Schmidt RE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr HIV/AIDS Rep
JT  - Current HIV/AIDS reports
JID - 101235661
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/diagnosis/drug therapy/immunology
MH  - Anti-Infective Agents/therapeutic use
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Autoimmune Diseases/diagnosis/drug therapy/*immunology
MH  - Diagnosis, Differential
MH  - HIV Infections/*drug therapy/immunology
MH  - Humans
MH  - Immunocompetence/*drug effects/immunology
MH  - Immunosuppressive Agents/therapeutic use
MH  - Inflammation/diagnosis/drug therapy/*immunology
RF  - 50
EDAT- 2005/08/11 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/11 09:00
PHST- 2005/08/11 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/11 09:00 [entrez]
AID - 10.1007/s11904-004-0018-7 [doi]
PST - ppublish
SO  - Curr HIV/AIDS Rep. 2004 Sep;1(3):122-7. doi: 10.1007/s11904-004-0018-7.