PMID- 16093487
OWN - NLM
STAT- MEDLINE
DCOM- 20051028
LR  - 20071115
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1047
DP  - 2005 Jun
TI  - Calcium signaling in cardiac ventricular myocytes.
PG  - 86-98
AB  - Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In 
      cardiac muscle Ca is a direct central mediator of electrical activation, ion 
      channel gating, and excitation-contraction (E-C) coupling that all occur on the 
      millisecond time scale. The key amplification step in E-C coupling is under tight 
      control of very local [Ca]. Ca also directly activates signaling via kinases and 
      phosphatases (e.g., Ca-calmodulin-dependent protein kinase [CaMKII] and 
      calcineurin) that occur over a longer time scale (seconds to minutes), and the 
      co-localization of these Ca-dependent modulators to their targets and to Ca is 
      also critical in distinct signaling pathways. Finally, Ca-dependent signaling is 
      also involved in long-term (minutes to hours/days) alterations in gene expression 
      (or excitation-transcription coupling). These pathways are involved in 
      hypertrophy and heart failure, and they can alter the expression of some of the 
      key Ca regulatory proteins involved in E-C coupling and their regulation by 
      kinases and phosphatases. There may again be physical microenvironments involved 
      in this nuclear transcription, such that they sense a discrete Ca signal that is 
      distinct from that involved in E-C coupling. In this way cells can use Ca 
      signaling in multiple ways that function in spatially and temporally distinct 
      manners.
FAU - Bers, Donald M
AU  - Bers DM
AD  - Department of Physiology, Loyola University Chicago, 2160 S. First Ave, Maywood, 
      IL 60153, USA. dbers@lumc.edu
FAU - Guo, Tao
AU  - Guo T
LA  - eng
GR  - HL-30077/HL/NHLBI NIH HHS/United States
GR  - HL-64724/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Calcium Signaling/*physiology
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Heart Ventricles/*cytology
MH  - Humans
MH  - Myocardial Contraction/physiology
MH  - Myocytes, Cardiac/metabolism/*physiology
MH  - Phosphorylation
RF  - 90
EDAT- 2005/08/12 09:00
MHDA- 2005/10/29 09:00
CRDT- 2005/08/12 09:00
PHST- 2005/08/12 09:00 [pubmed]
PHST- 2005/10/29 09:00 [medline]
PHST- 2005/08/12 09:00 [entrez]
AID - 1047/1/86 [pii]
AID - 10.1196/annals.1341.008 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2005 Jun;1047:86-98. doi: 10.1196/annals.1341.008.