PMID- 16094711
OWN - NLM
STAT- MEDLINE
DCOM- 20051102
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 30
DP  - 2005 Aug 14
TI  - Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma.
PG  - 4689-92
AB  - AIM: To investigate the role of survivin expression in the pathogenesis of 
      colorectal carcinoma. METHODS: Immunohistochemistry S-P method and terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were used to 
      detect the expression of survivin and apoptotic cell in situ in colorectal 
      cancerous tissues, para-cancerous tissues and normal tissues of 48 cases of 
      colorectal carcinoma. RESULTS: The survivin positive unit (PU) was higher in 
      cancerous tissues (38.76+/-5.14) than in para-cancerous (25.17+/-7.26) or normal 
      tissues (0.57+/-0.03) (P<0.05). The apoptosis index (AI) of para-cancerous 
      tissues was (7.51+/-2.63%) higher than cancerous tissues (4.65+/-1.76%). The 
      expression of survivin was associated with pathological grade, lymph node 
      metastasis and Dukes stage of colorectal carcinoma. CONCLUSION: Survivin 
      expression may play an important role in carcinogenesis of colorectal carcinoma 
      and may be associated with malignant biological behaviors of colorectal 
      carcinoma.
FAU - Tan, Hai-Yan
AU  - Tan HY
AD  - Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      Province, China. liu9861jun@yahoo.com.cn
FAU - Liu, Jun
AU  - Liu J
FAU - Wu, Shan-Min
AU  - Wu SM
FAU - Luo, He-Sheng
AU  - Luo HS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Apoptosis
MH  - Colorectal Neoplasms/etiology/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Male
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
MH  - Survivin
PMC - PMC4615412
EDAT- 2005/08/12 09:00
MHDA- 2005/11/03 09:00
PMCR- 2005/08/14
CRDT- 2005/08/12 09:00
PHST- 2005/08/12 09:00 [pubmed]
PHST- 2005/11/03 09:00 [medline]
PHST- 2005/08/12 09:00 [entrez]
PHST- 2005/08/14 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i30.4689 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Aug 14;11(30):4689-92. doi: 10.3748/wjg.v11.i30.4689.