PMID- 16094717
OWN - NLM
STAT- MEDLINE
DCOM- 20051102
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 30
DP  - 2005 Aug 14
TI  - Long-term omeprazole and esomeprazole treatment does not significantly increase 
      gastric epithelial cell proliferation and epithelial growth factor receptor 
      expression and has no effect on apoptosis and p53 expression.
PG  - 4721-6
AB  - AIM: To study the effect of proton pump inhibitor (PPI) treatment on patients 
      with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal 
      growth factor receptor (EGFR) expression. METHODS: After informed consent was 
      obtained, gastric biopsies of the antrum were taken from patients with reflux 
      oesophagitis prior to and after 6 mo of 20 mg omeprazole (n = 14) or 40 mg 
      esomeprazole (n = 12) therapy. Patients did not take any other medications known 
      to affect the gastric mucosa. All patients were Helicobacter pylori negative as 
      confirmed by rapid urease test and histology, respectively. Cell proliferation, 
      apoptosis, EGFR, and p53 expression were measured by immunohistochemical 
      techniques. At least 600 glandular epithelial cells were encountered and results 
      were expressed as percentage of total cells counted. Was considered statistically 
      significant. RESULTS: Although there was a trend towards increase of cell 
      proliferation and EGFR expression both in omeprazole and esomeprazole treated 
      group, the difference was not statistically significant. Neither apoptosis nor 
      p53 expression was affected. CONCLUSION: Long-term PPI treatment does not 
      significantly increase gastric epithelial cell proliferation and EGFR expression 
      and has no effect on apoptosis and p53 expression.
FAU - Hritz, Istvan
AU  - Hritz I
AD  - 2nd Dept Medicine, Semmelweis University, Budapest, Hungary. 
      hritz.istvan@freemail.hu
FAU - Herszenyi, Laszlo
AU  - Herszenyi L
FAU - Molnar, Bela
AU  - Molnar B
FAU - Tulassay, Zsolt
AU  - Tulassay Z
FAU - Pronai, Laszlo
AU  - Pronai L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - KG60484QX9 (Omeprazole)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adult
MH  - Apoptosis/drug effects
MH  - Cell Proliferation/drug effects
MH  - Epithelial Cells/drug effects
MH  - ErbB Receptors/metabolism
MH  - Esomeprazole
MH  - Female
MH  - Gastric Mucosa/*drug effects/metabolism/pathology
MH  - Gastroesophageal Reflux/drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/administration & dosage/*adverse effects
MH  - Proton Pump Inhibitors
MH  - Tumor Suppressor Protein p53/metabolism
PMC - PMC4615418
EDAT- 2005/08/12 09:00
MHDA- 2005/11/03 09:00
PMCR- 2005/08/14
CRDT- 2005/08/12 09:00
PHST- 2005/08/12 09:00 [pubmed]
PHST- 2005/11/03 09:00 [medline]
PHST- 2005/08/12 09:00 [entrez]
PHST- 2005/08/14 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i30.4721 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Aug 14;11(30):4721-6. doi: 10.3748/wjg.v11.i30.4721.