PMID- 16096331
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20220311
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 65
IP  - 4
DP  - 2006 Apr
TI  - Tumour necrosis factor alpha is expressed in refractory skin lesions from 
      patients with subacute cutaneous lupus erythematosus.
PG  - 545-8
AB  - OBJECTIVES: To investigate whether tumour necrosis factor alpha (TNFalpha) is 
      expressed in subacute cutaneous lupus erythematosus (SCLE) skin lesions. METHODS: 
      The in situ expression of TNFalpha in refractory lesional and non-lesional skin 
      biopsy specimens from patients with SCLE was analysed using an 
      immunohistochemical approach. At the time of biopsy these patients were receiving 
      treatment with systemic medications such as antimalarial agents, 
      immunosuppressive drugs, and thalidomide. Expression of TNFalpha was also 
      evaluated in cutaneous lesions of patients with other inflammatory and neoplastic 
      skin diseases as controls. RESULTS: The data showed that refractory lesional skin 
      tissue from patients with SCLE displays a strongly positive distribution of 
      TNFalpha, particularly within the epidermis. No prominent staining was seen in 
      non-lesional skin from the same group of patients or in cutaneous lesions from 
      the control group. CONCLUSIONS: These findings suggest that TNFalpha is localised 
      and produced by epidermal cells within SCLE skin lesions and support its 
      potential role in the pathogenesis of SCLE. The tissue localisation of TNFalpha 
      may represent a potential therapeutic target providing a new perspective in the 
      treatment of refractory skin lesions in patients with SCLE.
FAU - Zampieri, S
AU  - Zampieri S
AD  - Department of Clinical and Experimental Medicine, University of Padova, Italy.
FAU - Alaibac, M
AU  - Alaibac M
FAU - Iaccarino, L
AU  - Iaccarino L
FAU - Rondinone, R
AU  - Rondinone R
FAU - Ghirardello, A
AU  - Ghirardello A
FAU - Sarzi-Puttini, P
AU  - Sarzi-Puttini P
FAU - Peserico, A
AU  - Peserico A
FAU - Doria, A
AU  - Doria A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050811
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Antirheumatic Agents/therapeutic use
MH  - Autoantibodies/analysis
MH  - Epidermis/immunology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lupus Erythematosus, Cutaneous/drug therapy/*immunology
MH  - Lymphocyte Subsets/pathology
MH  - Middle Aged
MH  - Skin/*immunology
MH  - Tumor Necrosis Factor-alpha/*metabolism
PMC - PMC1798098
COIS- Competing interest: None.
EDAT- 2005/08/13 09:00
MHDA- 2006/04/21 09:00
PMCR- 2009/04/01
CRDT- 2005/08/13 09:00
PHST- 2005/08/13 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2005/08/13 09:00 [entrez]
PHST- 2009/04/01 00:00 [pmc-release]
AID - ard.2005.039362 [pii]
AID - ar39362 [pii]
AID - 10.1136/ard.2005.039362 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2006 Apr;65(4):545-8. doi: 10.1136/ard.2005.039362. Epub 2005 Aug 
      11.