PMID- 16100172
OWN - NLM
STAT- MEDLINE
DCOM- 20050906
LR  - 20161124
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 128
IP  - 2
DP  - 2005 Aug
TI  - Enhanced coronary calcification determined by electron beam CT is strongly 
      related to endothelial dysfunction in patients with suspected coronary artery 
      disease.
PG  - 810-5
AB  - BACKGROUND: Coronary artery calcification determined by electron beam CT (EBCT) 
      is strongly associated with total plaque burden but is not related to systemic 
      vascular inflammation. AIMS: We sought to test the hypothesis that enhanced 
      coronary artery calcification, a marker of atherosclerosis and plaque burden, was 
      related to endothelial dysfunction in patients with suspected coronary artery 
      disease (CAD). METHODS AND RESULTS: One hundred twenty-four subjects with 
      suspected CAD were enrolled. Coronary artery calcification was detected by EBCT. 
      A noninvasive method of brachial ultrasound was used to measure 
      endothelium-dependent flow-mediated vasodilation (FMD) and 
      endothelium-independent nitroglycerin-mediated vasodilation (NMD). Serum 
      high-sensitivity C-reactive protein (hsCRP) and monocyte chemoattractant 
      protein-1 (MCP-1) levels were also determined. Of the 124 patients, the calcium 
      scores ranged from 0 to 4,394. All subjects were classified into three groups 
      according to coronary calcium scores: group 1, score 0 (n = 26); group 2, scores 
      1 to 199 (n = 50); group 3, scores > or = 200 (n = 48). There was an inverse 
      association between the degree of coronary artery calcification and the 
      endothelium-dependent FMD in the three groups (6.9 +/- 0.6% vs 5.3 +/- 0.3% vs 
      3.7 +/- 0.3%, respectively; p < 0.001) but not the endothelium-independent NMD. 
      Besides, no significant difference in serum levels of hsCRP and MCP-1 were found 
      among the three groups. However, both the serum levels of hsCRP and MCP-1 were 
      correlated significantly with endothelium-dependent FMD (r = - 0.211, p = 0.019; 
      and r = - 0.188, p = 0.037, respectively). By multivariate analysis, enhanced 
      coronary calcification was a strong independent predictor of endothelial 
      dysfunction (p < 0.001). CONCLUSION: Enhanced coronary artery calcification 
      strongly predicted endothelial dysfunction in patients with suspected CAD. Also, 
      serum levels of hsCRP and MCP-1 were significantly correlated with endothelial 
      function. These findings suggested that both calcium deposition and inflammation 
      were involved in endothelial dysfunction.
FAU - Huang, Po-Hsun
AU  - Huang PH
AD  - Division of Cardiology, Department of Internal Medicine, Taipei Veterans General 
      Hospital, No. 201, Sec. 2, Shih-Pai Rd, Taipei, Taiwan.
FAU - Chen, Lung-Ching
AU  - Chen LC
FAU - Leu, Hsin-Bang
AU  - Leu HB
FAU - Ding, Philip Yu-An
AU  - Ding PY
FAU - Chen, Jaw-Wen
AU  - Chen JW
FAU - Wu, Tao-Cheng
AU  - Wu TC
FAU - Lin, Shing-Jong
AU  - Lin SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/*physiology
MH  - Calcinosis/*diagnostic imaging
MH  - Chemokine CCL2/*physiology
MH  - Coronary Artery Disease/diagnostic imaging/physiopathology
MH  - Coronary Disease/*diagnostic imaging/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Tomography, X-Ray Computed
EDAT- 2005/08/16 09:00
MHDA- 2005/09/07 09:00
CRDT- 2005/08/16 09:00
PHST- 2005/08/16 09:00 [pubmed]
PHST- 2005/09/07 09:00 [medline]
PHST- 2005/08/16 09:00 [entrez]
AID - S0012-3692(15)50430-3 [pii]
AID - 10.1378/chest.128.2.810 [doi]
PST - ppublish
SO  - Chest. 2005 Aug;128(2):810-5. doi: 10.1378/chest.128.2.810.