PMID- 16101510
OWN - NLM
STAT- MEDLINE
DCOM- 20060308
LR  - 20190823
IS  - 0929-8673 (Print)
IS  - 0929-8673 (Linking)
VI  - 12
IP  - 16
DP  - 2005
TI  - Dendritic cells as pharmacological targets for the generation of regulatory 
      immunosuppressive effectors. New implications for allo-transplantation.
PG  - 1921-30
AB  - Dendritic cells (DCs) play a central role in the establishment of 
      tolerance/immunity, because they activate naive T cells (TCs). Therefore, the 
      pharmacological modulation of DCs has become a major field of interest in 
      immunology. A large body of literature has arisen from the studies of DC biology 
      during immunosuppressive drug treatment. Immunosuppressive drugs have improved 
      the therapeutic management of allograft organ transplantation and autoimmune 
      diseases, significantly. There is now strong evidence that, DCs might be the key 
      for antigen specific tolerance induction. Recently, the existence of a population 
      of DCs that migrate to the regional lymph node in the steady state has been 
      identified. Such steady state immature migrating DCs are loaded with tissue 
      antigens and deliver self-antigens towards secondary lymphatic organs and might 
      educate TCs towards self-tolerance. Latest experimental data from rodent solid 
      organ allo-transplantation supports the idea, that DCs might even become 
      regulatory DCs towards foreign antigen specific tolerance induction. Apparently, 
      regulatory donor DCs invade host secondary lymphatic organs where they might 
      eventually educate host TCs towards foreign antigen specific tolerance. 
      Seemingly, it depends on the DC maturation state whether pharmacologically 
      modulated DCs induce antigen specific long-term tolerance in allo-transplantation 
      solid organ transplantation. Several authors reported a positive self-limiting 
      feedback loop between tolerogenic DCs and allo-specific regulatory TCs. Thus, the 
      DC-TC network appears as an exceptionally good target for pharmacological 
      manipulations. Here we review how immunosuppressive agents interfere with DC 
      maturation, migration and homeostasis. We are developing a rational to select 
      different drugs for the generation of regulatory DCs, for allo-transplantation 
      clinical settings.
FAU - Schlichting, C L
AU  - Schlichting CL
AD  - Department of Surgery, Division of Transplantation Surgery, School of Medicine, 
      University Hospital, University Rostock, Schillingallee 35, 18055 Rostock, 
      Germany. christoph.schlichting@drschlichting.de
FAU - Schareck, W D
AU  - Schareck WD
FAU - Nickel, T
AU  - Nickel T
FAU - Weis, M
AU  - Weis M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/cytology/*drug effects/*immunology
MH  - Humans
MH  - Immunosuppressive Agents/*pharmacology
MH  - Transplantation, Homologous/*immunology
RF  - 146
EDAT- 2005/08/17 09:00
MHDA- 2006/03/09 09:00
CRDT- 2005/08/17 09:00
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2006/03/09 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
AID - 10.2174/0929867054546627 [doi]
PST - ppublish
SO  - Curr Med Chem. 2005;12(16):1921-30. doi: 10.2174/0929867054546627.